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Roger F Butterworth Selected Research

Neurotransmitter Agents (Neurotransmitter)

6/2013Parkinsonism in cirrhosis: pathogenesis and current therapeutic options.
7/2012Reduced brain levels of DHEAS in hepatic coma patients: significance for increased GABAergic tone in hepatic encephalopathy.
10/2007Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions.
9/2006Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
6/2006An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons.
5/2006Neurobiological characterization of an azoxymethane mouse model of acute liver failure.
12/2004Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy.
12/2003Pathogenesis of hepatic encephalopathy: update on molecular mechanisms.
9/2003Cell-selective effects of ammonia on glutamate transporter and receptor function in the mammalian brain.
2/2003Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study.
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Roger F Butterworth Research Topics

Disease

30Acute Liver Failure (Fulminant Hepatic Failure)
09/2014 - 08/2002
28Brain Edema (Cerebral Edema)
03/2015 - 07/2002
25Hepatic Encephalopathy
09/2015 - 05/2002
22Hypothermia
03/2015 - 12/2002
20Liver Failure
09/2014 - 07/2002
17Coma (Comas)
07/2012 - 07/2002
12Hyperammonemia
09/2014 - 05/2002
9Thiamine Deficiency
12/2010 - 07/2004
9End Stage Liver Disease
07/2009 - 08/2002
7Liver Diseases (Liver Disease)
03/2015 - 01/2003
7Inflammation
09/2013 - 04/2005
5Fibrosis (Cirrhosis)
09/2015 - 01/2003
4Malnutrition
03/2015 - 12/2003
4Wernicke Encephalopathy (Wernicke's Encephalopathy)
12/2010 - 03/2008
3Stroke (Strokes)
08/2014 - 12/2004
3Nervous System Diseases (Neurological Disorders)
03/2014 - 09/2003
3Intracranial Hypertension
06/2012 - 12/2005
3Lactic Acidosis
03/2008 - 01/2005
3Gliosis
12/2003 - 06/2002
3Seizures (Seizure)
09/2003 - 05/2002
3Reye Syndrome (Reye's Syndrome)
09/2003 - 08/2002
3Inborn Urea Cycle Disorders
09/2003 - 08/2002
2Sarcopenia
03/2015 - 06/2014
2Parkinsonian Disorders (Parkinsonism)
01/2014 - 06/2013
2Infection
06/2013 - 11/2008
2Necrosis
01/2012 - 11/2008
2Herpes Zoster
10/2009 - 09/2009
2Edema
07/2009 - 04/2005
2Hyperglycemia
04/2005 - 12/2004
2Ischemia
04/2005 - 12/2004
2Brain Ischemia (Cerebral Ischemia)
04/2005 - 12/2004

Drug/Important Bio-Agent (IBA)

29AmmoniaIBA
09/2014 - 05/2002
14Glutamic Acid (Glutamate)FDA Link
03/2014 - 06/2002
13Messenger RNA (mRNA)IBA
03/2014 - 06/2002
13Neurotransmitter Agents (Neurotransmitter)IBA
06/2013 - 08/2002
12CytokinesIBA
09/2013 - 12/2007
11Thiamine (Aneurin)FDA Link
01/2014 - 07/2004
10Proteins (Proteins, Gene)IBA
03/2014 - 08/2003
9GABA-A Receptors (GABA(A) Receptor)IBA
07/2012 - 05/2002
8Glutamine (L-Glutamine)FDA Link
09/2014 - 12/2002
8Lactic AcidFDA LinkGeneric
09/2013 - 02/2003
8Glucose (Dextrose)FDA LinkGeneric
12/2008 - 12/2002
7Minocycline (Cyclops)FDA LinkGeneric
03/2015 - 04/2009
6ManganeseIBA
01/2014 - 01/2003
6Acetylcysteine (Siran)FDA LinkGeneric
09/2013 - 10/2007
6N-Methylaspartate (NMDA)IBA
07/2010 - 05/2002
6salicylhydroxamic acid (SHAM)IBA
12/2009 - 12/2002
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2014 - 11/2008
5Amino AcidsFDA Link
01/2010 - 02/2003
5BenzodiazepinesIBA
06/2006 - 11/2003
4TNFR-Fc fusion protein (etanercept)FDA Link
03/2015 - 01/2012
4Pregnanolone (Allopregnanolone)IBA
07/2012 - 11/2003
4AzoxymethaneIBA
06/2010 - 05/2006
4Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA
03/2009 - 05/2002
4gamma-Aminobutyric Acid (GABA)IBA
07/2008 - 02/2003
3Anti-Inflammatory Agents (Anti-Inflammatories)IBA
03/2015 - 04/2009
3ZincIBA
03/2015 - 04/2005
3Dietary ProteinsIBA
09/2014 - 12/2007
3Protein Isoforms (Isoforms)IBA
09/2014 - 07/2009
3Glial Fibrillary Acidic ProteinIBA
03/2014 - 06/2002
3Anti-Bacterial Agents (Antibiotics)IBA
01/2014 - 12/2002
3Lactulose (Duphalac)FDA LinkGeneric
01/2014 - 07/2010
3ornithylaspartateIBA
01/2014 - 12/2002
3Glutathione (Reduced Glutathione)IBA
06/2010 - 01/2007
3Acetaminophen (Paracetamol)FDA LinkGeneric
06/2010 - 01/2007
3occludinIBA
10/2009 - 07/2009
3Cyclooxygenase 2 (Cyclooxygenase-2)IBA
06/2008 - 03/2003
3PregnenoloneIBA
03/2008 - 05/2005
3LigandsIBA
09/2006 - 12/2004
3Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2004 - 11/2002
2Vitamin A (Retinol)FDA LinkGeneric
03/2015 - 06/2014
2Riboflavin (Vitamin B2)FDA LinkGeneric
03/2015 - 06/2014
2Cysteine (L-Cysteine)FDA Link
03/2015 - 06/2013
2Urea (Carbamide)FDA LinkGeneric
09/2014 - 07/2002
2Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA
09/2014 - 06/2006
2Immunoglobulin G (IgG)IBA
03/2014 - 10/2009
2Excitatory Amino AcidsIBA
03/2014 - 06/2002
2Matrix Metalloproteinase 9 (Gelatinase B)IBA
03/2014 - 10/2009
2rifaximin (L 105)FDA Link
09/2013 - 02/2011
2Interleukin-6 (Interleukin 6)IBA
09/2013 - 01/2012
2Indomethacin (Indometacin)FDA LinkGeneric
04/2011 - 10/2007
2Caveolin 1IBA
12/2010 - 07/2009
2SteroidsIBA
07/2010 - 12/2007
2Interleukin-1beta (Interleukin 1 beta)IBA
01/2010 - 04/2005
2Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
07/2009 - 07/2004
2InterleukinsIBA
04/2009 - 11/2008
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
11/2008 - 12/2007
2Sulfhydryl Compounds (Thiols)IBA
11/2008 - 01/2003
2Aspartic Acid (Aspartate)FDA Link
07/2008 - 09/2003
2MuscimolIBA
09/2006 - 11/2003
2Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
04/2006 - 08/2003
2Flumazenil (Romazicon)FDA LinkGeneric
12/2005 - 07/2005
2Superoxide DismutaseIBA
04/2005 - 12/2004
2Superoxides (Superoxide)IBA
04/2005 - 12/2004
2Serotonin (5 Hydroxytryptamine)IBA
05/2004 - 07/2002

Therapy/Procedure

8Liver Transplantation
03/2015 - 01/2003
5Ligation
07/2009 - 08/2002
4Surgical Portacaval Shunt (Portacaval Anastomosis)
07/2009 - 08/2002
3Transplants (Transplant)
03/2015 - 07/2009
2Transplantation (Transplant Recipients)
03/2015 - 06/2014