D Allan Butterfield Selected Research

Alzheimer Disease (Alzheimer's Disease)

10/2008	Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease.
04/2008	Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease.
01/2008	Alterations of some membrane transport proteins in Alzheimer's disease: role of amyloid beta-peptide.
01/2008	Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease.
12/2007	Natural antioxidants in Alzheimer's disease.
09/2007	Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment.
08/2007	Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder.
05/2007	An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach.
05/2007	Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease.
05/2007	Proteomics analysis of the Alzheimer's disease hippocampal proteome.
02/2007	Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.
12/2006	Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment.
12/2006	In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidative stress-related neurodegenerative disorders.
11/2006	Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD.
09/2006	Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): implications for Alzheimer's disease.
08/2006	Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.
05/2006	Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease.
04/2006	Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach.
03/2006	Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
06/2005	Protection against amyloid beta-peptide (1-42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: implications for Alzheimer's disease.
05/2005	Proteomic identification of proteins oxidized by Abeta(1-42) in synaptosomes: implications for Alzheimer's disease.
03/2005	Gamma-glutamylcysteine ethyl ester-induced up-regulation of glutathione protects neurons against Abeta(1-42)-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.
10/2004	Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain.
09/2004	APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease.
04/2004	Modulation of phospholipid asymmetry in synaptosomal membranes by the lipid peroxidation products, 4-hydroxynonenal and acrolein: implications for Alzheimer's disease.
02/2004	4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease.
12/2003	Amyloid beta-peptide [1-42]-associated free radical-induced oxidative stress and neurodegeneration in Alzheimer's disease brain: mechanisms and consequences.
12/2003	Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease.
06/2003	Proteomic identification of nitrated proteins in Alzheimer's disease brain.
05/2003	Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model.
01/2003	Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease.
12/2002	Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review.
09/2002	Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71.
09/2002	Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death.
08/2002	Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
06/2002	Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress.
06/2002	Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists.
05/2002	Oxidative stress in synaptosomal proteins from mutant presenilin-1 knock-in mice: implications for familial Alzheimer's disease.

Articles by Research Topic

Disease

38	Alzheimer Disease (Alzheimer's Disease) 10/2008 - 05/2002
6	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2006 - 09/2002
2	Neoplasms (Cancer) 06/2007 - 11/2005
2	Parkinson Disease (Parkinson's Disease) 07/2006 - 04/2005
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 08/2005 - 04/2005
1	Tissue Adhesions 05/2008
1	Brain Injuries (Brain Injury) 05/2007
1	AIDS Dementia Complex 03/2007
1	Lentivirus Infections 07/2005
1	Demyelinating Diseases (Demyelinating Disease) 10/2004
1	Syndrome 03/2004
1	Huntington Disease (Huntington's Disease) 06/2002
1	Spinal Cord Injuries (Spinal Cord Injury) 04/2002

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)IBA 10/2008 - 05/2002
13	Amyloid (Amyloid Fibrils)IBA 01/2008 - 06/2002
3	AntioxidantsIBA 01/2008 - 12/2003
2	Acetylcarnitine (Alcar)IBA 02/2007 - 08/2006
2	Thioctic Acid (Lipoic Acid)IBA 02/2007 - 01/2005
2	tricyclodecane-9-yl-xanthogenateIBA 12/2006 - 06/2005
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 08/2006 - 03/2006
2	Glutathione (Reduced Glutathione)IBA 07/2006 - 03/2005
2	gamma-glutamylcysteineIBA 07/2006 - 03/2005
2	ethyl ferulateIBA 03/2006 - 06/2005
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2006 - 05/2004
2	Presenilin-1IBA 03/2006 - 05/2002
2	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 04/2004 - 02/2004
2	Acrolein (Aqualin)IBA 04/2004 - 01/2003
1	PeptidesIBA 10/2008
1	Biological Markers (Surrogate Marker)IBA 10/2008
1	Aluminum Oxide (Sapphire)IBA 05/2008
1	Membrane Transport Proteins (Biological Pump)IBA 01/2008
1	3-nitrotyrosineIBA 05/2007
1	ProteomeIBA 05/2007
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 05/2007
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 03/2007
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 07/2006
1	Kainic Acid (Kainate)IBA 03/2006
1	Carbon MonoxideIBA 03/2006
1	2,2'-azobis(2-amidinopropane) (ABAP)IBA 03/2006
1	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2005
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 07/2005
1	amyloid beta-protein (1-42)IBA 05/2005
1	alpha-SynucleinIBA 04/2005
1	Glycoproteins (Glycoprotein)IBA 10/2004
1	Dietary CholesterolIBA 09/2004
1	UbiquitinIBA 03/2004
1	Histones (Histone)IBA 02/2004
1	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 12/2003
1	NAD (NADH)IBA 01/2003
1	Vitamin E FDA Link 09/2002
1	3-nitropropionic acidIBA 06/2002
1	BB Form Creatine KinaseIBA 04/2002

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 06/2007