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Santina Bruzzone Selected Research

NAD (NADH)

9/2015Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
8/2015Selectivity hot-spots of sirtuin catalytic cores.
12/2014Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity.
6/2014Discovery of novel and selective SIRT6 inhibitors.
4/2014A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis.
9/2013CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells.
11/2012The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
1/2011Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells.
11/2010Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.
1/2009Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.
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Santina Bruzzone Research Topics

Disease

6Neoplasms (Cancer)
08/2015 - 01/2009
6Inflammation
06/2014 - 11/2008
4Leukemia
09/2015 - 11/2010
3Hematologic Neoplasms (Hematological Malignancy)
04/2014 - 06/2009
3Insulinoma
03/2012 - 10/2009
2Pancreatic Neoplasms (Pancreatic Cancer)
09/2015 - 11/2012
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
09/2015 - 11/2010
2Genomic Instability
08/2015 - 06/2014
2Hyperglycemia
01/2015 - 03/2012
2Atherosclerosis
02/2014 - 06/2009
2Ischemia
02/2013 - 01/2013
1Skin Neoplasms (Skin Cancer)
09/2015
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/2015
1Gestational Diabetes (Gestational Diabetes Mellitus)
01/2015
1Breast Neoplasms (Breast Cancer)
12/2014
1Lymphoma (Lymphomas)
04/2014
1Atherosclerotic Plaque (Atheroma)
02/2014
1Myocardial Infarction
02/2013
1Acute Lung Injury
01/2013
1Immune System Diseases (Immune Disorders)
01/2013
1Systemic Scleroderma (Systemic Sclerosis)
05/2012
1Silicosis
03/2012
1Lung Diseases (Lung Disease)
03/2012
1Alzheimer Disease (Alzheimer's Disease)
05/2009
1Astrocytoma (Pilocytic Astrocytoma)
10/2006
1Neurodegenerative Diseases (Neurodegenerative Disease)
10/2006

Drug/Important Bio-Agent (IBA)

11NAD (NADH)IBA
09/2015 - 10/2006
7Nicotinamide PhosphoribosyltransferaseIBA
09/2015 - 01/2009
5Abscisic AcidIBA
01/2015 - 06/2009
4N- (4- (1- benzoylpiperidin- 4- yl)butyl)- 3- (pyridin- 3- yl)acrylamideIBA
09/2015 - 06/2009
3SirtuinsIBA
08/2015 - 01/2011
3Glucose (Dextrose)FDA LinkGeneric
01/2015 - 11/2008
3Cyclic ADP-Ribose (cADPR)IBA
06/2009 - 10/2006
2Histone Deacetylases (Histone Deacetylase)IBA
11/2012 - 01/2011
2HormonesIBA
03/2012 - 11/2008
2lanthionineIBA
11/2011 - 10/2009
2LigasesIBA
11/2011 - 10/2009
2Insulin (Novolin)FDA Link
10/2009 - 11/2008
1CytotoxinsIBA
09/2015
1gemcitabineFDA Link
09/2015
1Cyclosporine (Ciclosporin)FDA LinkGeneric
09/2015
1DNA (Deoxyribonucleic Acid)IBA
08/2015
12,2'-azobis(2-amidinopropane) (ABAP)IBA
01/2015
1Caspase 3 (Caspase-3)IBA
04/2014
1CollagenIBA
02/2014
1CXC ChemokinesIBA
02/2014
1Apolipoproteins E (ApoE)IBA
02/2014
1ZymosanIBA
11/2013
1Transcription Factors (Transcription Factor)IBA
11/2013
1fluridoneIBA
11/2013
1Nicotinamide MononucleotideIBA
09/2013
1Niacinamide (Nicotinamide)FDA LinkGeneric
09/2013
1Reactive Oxygen Species (Oxygen Radicals)IBA
02/2013
1Chemotactic FactorsIBA
01/2013
1Proteins (Proteins, Gene)IBA
01/2013
1Neutralizing AntibodiesIBA
01/2013
1EnzymesIBA
01/2013
1ChemokinesIBA
11/2012
1Interleukin-8 (Interleukin 8)IBA
11/2012
1QuartzIBA
03/2012
1Prostaglandins E (PGE)IBA
03/2012
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2012
1Glucagon-Like Peptide 1 (GLP 1)IBA
03/2012
1sirtinolIBA
01/2011
1Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
01/2011
1Histone Deacetylase InhibitorsIBA
01/2011
1Butyrates (Butyrate)IBA
01/2011
1vorinostat (suberoylanilide hydroxamic acid)FDA Link
01/2011
1cambinolIBA
01/2011
1SodiumIBA
01/2011
1Adenosine Triphosphate (ATP)IBA
11/2010
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
06/2009
1NF-kappa B (NF-kB)IBA
06/2009
1Dinoprostone (PGE2)FDA Link
06/2009
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
06/2009
1peptide FIBA
05/2009
1Amyloid (Amyloid Fibrils)IBA
05/2009
1Tetradecanoylphorbol AcetateIBA
05/2009