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Angela Brodie Selected Research

letrozole (Femara)

11/2015Seribantumab, an Anti-ERBB3 Antibody, Delays the Onset of Resistance and Restores Sensitivity to Letrozole in an Estrogen Receptor-Positive Breast Cancer Model.
8/2015Histone deacetylase inhibitor entinostat in combination with a retinoid downregulates HER2 and reduces the tumor initiating cell population in aromatase inhibitor-resistant breast cancer.
12/2011Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer.
1/2011GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells.
2/2010Aromatase resistance mechanisms in model systems in vivo.
2/2010Understanding resistance to endocrine agents: molecular mechanisms and potential for intervention.
1/2010Sensitivity to the aromatase inhibitor letrozole is prolonged after a "break" in treatment.
2/2009Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen.
2/2009Aromatase inhibitors and breast cancer.
1/2009The Coffey Lecture: steroidogenic enzyme inhibitors and hormone dependent cancer.
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Angela Brodie Research Topics

Disease

30Breast Neoplasms (Breast Cancer)
11/2015 - 03/2002
28Neoplasms (Cancer)
11/2015 - 03/2002
3Prostatic Neoplasms (Prostate Cancer)
01/2009 - 07/2005
1Tics (Tic)
08/2015
1Stroke (Strokes)
07/2015
1Inflammation
11/2012
1Ductal Carcinoma
01/2011
1Carcinoma (Carcinomatosis)
09/2010
1Body Weight (Weight, Body)
08/2004
1Endometrial Neoplasms (Endometrial Cancer)
08/2004
1Osteoporosis
08/2004
1Hypertrophy
08/2004

Drug/Important Bio-Agent (IBA)

24Aromatase (CYP19)IBA
11/2015 - 03/2002
22Estrogens (Estrogen)FDA Link
11/2015 - 01/2003
19letrozole (Femara)FDA LinkGeneric
11/2015 - 03/2002
17Aromatase InhibitorsIBA
07/2015 - 03/2002
16HormonesIBA
07/2015 - 08/2004
9TamoxifenFDA LinkGeneric
04/2012 - 01/2003
7trastuzumab (Herceptin)FDA Link
07/2011 - 02/2008
7Estrogen Receptor Modulators (Antiestrogen)IBA
02/2009 - 01/2003
5Proteins (Proteins, Gene)IBA
04/2013 - 01/2005
5Estrogen Receptor alphaIBA
02/2010 - 02/2008
4anastrozole (Arimidex)FDA LinkGeneric
04/2013 - 03/2002
3Insulin (Novolin)FDA Link
11/2012 - 05/2008
3Protein Kinases (Protein Kinase)IBA
07/2011 - 01/2005
3fulvestrant (Faslodex)FDA Link
09/2010 - 05/2007
2Androstenedione (4 Androstene 3,17 dione)IBA
04/2013 - 05/2007
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
12/2011 - 08/2006
2Estradiol (Estrace)FDA LinkGeneric
02/2010 - 02/2008
2AndrogensIBA
01/2009 - 08/2006
2matrigelIBA
08/2004 - 01/2003
1Neuregulin-1 (Neuregulin 1)IBA
11/2015
1N- (2- aminophenyl)- 4- (N- (pyridin- 3- ylmethoxycarbonyl)aminomethyl)benzamide (MS 275)IBA
08/2015
1Tretinoin (Retinoic Acid)FDA LinkGeneric
08/2015
1Histone Deacetylase InhibitorsIBA
08/2015
13,16-dihydroxyandrost-5-ene-17,19-dioneIBA
07/2015
1NF-E2-Related Factor 2IBA
07/2015
1Aldehyde DehydrogenaseIBA
07/2015
1AdiponectinIBA
11/2012
1Insulin-Like Growth Factor I (IGF-1)IBA
11/2012
1CytokinesIBA
11/2012
1LeptinIBA
11/2012
1BMS 754807IBA
12/2011
1granulin precursor proteinIBA
01/2011
1Endothelin A ReceptorIBA
09/2010
1Endothelin-1 (Endothelin 1)IBA
09/2010
1ZD4054IBA
09/2010
1Enzyme InhibitorsIBA
01/2009
1Phosphotransferases (Kinase)IBA
01/2009
1Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
01/2009
1Sirolimus (Rapamycin)FDA Link
05/2008
1atamestaneIBA
01/2008
1Toremifene (Fareston)FDA Link
01/2008
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
05/2007
1wortmanninIBA
05/2007
1Lysine (L-Lysine)FDA Link
08/2006
1Histones (Histone)IBA
08/2006
1Small Interfering RNA (siRNA)IBA
08/2006
1Carrier Proteins (Binding Protein)IBA
08/2006
1Cyclic AMP (AMP, Cyclic)IBA
08/2006
1Staphylococcal Protein A (A, Protein)IBA
07/2005
1Androgen Receptors (Androgen Receptor)IBA
07/2005
1Complement System Proteins (Complement)IBA
08/2004
1GonadotropinsIBA
08/2004
1exemestane (Aromasin)FDA Link
03/2002

Therapy/Procedure

12Heterologous Transplantation (Xenotransplantation)
11/2015 - 08/2003