Non-Steroidal Anti-Inflammatory Agents

Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or TYPE C PHOSPHOLIPASES or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)

Also Known As:

NSAIDs; Anti-Inflammatory Agents, Non-Steroidal; Anti Inflammatory Agents, Nonsteroidal; Antiinflammatory Agents, Non Steroidal; Antiinflammatory Agents, Nonsteroidal; Antirheumatic Agents, Non-Steroidal; Nonsteroidal Anti-Inflammatory Agents; Agents, Aspirin-Like; Agents, Non-Steroidal Anti-Inflammatory; Agents, Non-Steroidal Anti-Rheumatic; Agents, Non-Steroidal Antirheumatic; Agents, Nonsteroidal Anti-Inflammatory; Agents, Nonsteroidal Antiinflammatory; Analgesics, Anti Inflammatory; Anti Inflammatory Agents, Non Steroidal; Anti Rheumatic Agents, Non Steroidal; Anti-Inflammatory Agents, Nonsteroidal; Anti-Inflammatory Analgesics; Antirheumatic Agents, Non Steroidal; Aspirin Like Agents; Non Steroidal Anti Inflammatory Agents; Non-Steroidal Anti-Rheumatic Agents; Non-Steroidal Antirheumatic Agents; Nonsteroidal Anti Inflammatory Agents; Nonsteroidal Antiinflammatory Agents; Analgesics, Anti-Inflammatory; Anti-Rheumatic Agents, Non-Steroidal; Aspirin-Like Agents

Chemical Actions and Uses
- Pharmacologic Actions: 47
  - Therapeutic Uses: 200
    - Antirheumatic Agents: 1185
      - Non-Steroidal Anti-Inflammatory Agents: 5742
    - Anti-Inflammatory Agents: 1182
      - Non-Steroidal Anti-Inflammatory Agents: 5742
  - Physiological Effects of Drugs: 1
    - Peripheral Nervous System Agents
      - Sensory System Agents
        Analgesics: 5839
        Non-Narcotic Analgesics: 388
        Non-Steroidal Anti-Inflammatory Agents: 5742

Pascal Bordat Selected Research

Pascal Bordat Research Topics

Disease

Drug/Important Bio-Agent (IBA)