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David A Boothman Selected Research

NAD (NADH)

1/2015Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.
10/2013Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.
6/2012An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.
1/2011Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.
10/2010Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.
5/2010Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.
1/2009Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapy.
8/2007Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.
7/2007Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
7/2007An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.
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David A Boothman Research Topics

Disease

42Neoplasms (Cancer)
08/2015 - 09/2003
8Pancreatic Neoplasms (Pancreatic Cancer)
01/2015 - 01/2005
6Necrosis
01/2015 - 10/2010
6Prostatic Neoplasms (Prostate Cancer)
09/2013 - 03/2003
5Lung Neoplasms (Lung Cancer)
02/2015 - 07/2007
5Breast Neoplasms (Breast Cancer)
07/2014 - 03/2003
4Colonic Neoplasms (Colon Cancer)
04/2011 - 10/2003
3Glioblastoma (Glioblastoma Multiforme)
08/2013 - 04/2009
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2010 - 07/2007
2Genomic Instability
06/2014 - 12/2004
2Ataxia Telangiectasia (Louis Bar Syndrome)
01/2014 - 07/2007
2Glioma (Gliomas)
08/2013 - 05/2009
2Phototoxic Dermatitis (Phototoxicity)
12/2011 - 05/2011
2Neoplasm Metastasis (Metastasis)
03/2011 - 02/2010
1Adenocarcinoma
01/2015
1Sarcoma (Soft Tissue Sarcoma)
01/2015
1Anoxia (Hypoxia)
12/2011
1Ureteral Obstruction
03/2011
1Fibrosis (Cirrhosis)
03/2011
1Carcinoma (Carcinomatosis)
02/2010
1Brain Neoplasms (Brain Tumor)
05/2009
1Colorectal Neoplasms (Colorectal Cancer)
02/2009

Drug/Important Bio-Agent (IBA)

17benzoquinone (quinone)IBA
08/2015 - 01/2005
16beta-lapachoneIBA
10/2010 - 03/2003
14NAD (NADH)IBA
01/2015 - 01/2005
9MicellesIBA
08/2015 - 11/2006
9DNA (Deoxyribonucleic Acid)IBA
01/2015 - 07/2007
6Adenosine Triphosphate (ATP)IBA
02/2015 - 10/2010
6ClusterinIBA
09/2013 - 12/2004
5Reactive Oxygen Species (Oxygen Radicals)IBA
01/2015 - 10/2010
4NADP (NADPH)IBA
01/2015 - 10/2006
4Proteins (Proteins, Gene)IBA
01/2014 - 09/2003
3Carbon MonoxideIBA
07/2014 - 03/2008
3Transcription Factors (Transcription Factor)IBA
06/2014 - 09/2003
3Phosphotransferases (Kinase)IBA
01/2014 - 07/2007
3Poly Adenosine Diphosphate RiboseIBA
10/2013 - 09/2006
3Small Interfering RNA (siRNA)IBA
01/2011 - 01/2006
3PolymersIBA
01/2009 - 01/2006
2deoxynyboquinoneIBA
07/2014 - 06/2012
2Telomerase (Telomerase Reverse Transcriptase)IBA
01/2014 - 03/2008
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
01/2014 - 05/2009
2epidermal growth factor receptor VIIIIBA
08/2013 - 05/2009
2IonsIBA
01/2013 - 10/2010
2poly(lactide) (polylactide)IBA
12/2011 - 10/2007
2CalpainIBA
10/2010 - 03/2003
2Transforming Growth Factor beta1 (TGF beta 1)IBA
01/2010 - 12/2006
2Sirolimus (Rapamycin)FDA Link
10/2009 - 05/2009
2DNA-Activated Protein KinaseIBA
05/2009 - 07/2007
2lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
05/2009 - 07/2007
2NF-kappa B (NF-kB)IBA
04/2009 - 09/2003
2mu-calpainIBA
04/2005 - 03/2003
2OxidoreductasesIBA
01/2005 - 03/2003
1methoxyamineIBA
01/2015
1Dicumarol (Dicoumarol)FDA Link
01/2015
1Glutamine (L-Glutamine)FDA Link
01/2015
1Radiation-Sensitizing AgentsIBA
07/2014
1CD147 Antigens (Basigin)IBA
02/2014
1gemcitabineFDA Link
02/2014
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2014
1CatalaseIBA
10/2013
1NucleotidesIBA
10/2013
1docetaxel (Taxotere)FDA Link
09/2013
1temozolomide (Temodar)FDA LinkGeneric
08/2013
1Hemoglobins (Hemoglobin)IBA
06/2013
1OxygenIBA
06/2013
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
01/2013
1IronIBA
01/2013
1ArgonIBA
12/2011
11-phenyl-3,3-dimethyltriazene (PDT)IBA
05/2011
1protoporphyrin IXIBA
05/2011
1klotho proteinIBA
03/2011
1Cyclin-Dependent Kinase Inhibitor p16IBA
10/2010
1VimentinIBA
02/2010
1Cadherins (E-Cadherin)IBA
02/2010
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2010
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
05/2009
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
05/2009
1cyclic (arginyl- glycyl- aspartyl- phenylalanyl- lysyl)IBA
02/2009
1ORALIT (ORS)IBA
02/2009
1Biological Markers (Surrogate Marker)IBA
02/2009
1Interleukin-6 (Interleukin 6)IBA
02/2009
1Protein Isoforms (Isoforms)IBA
02/2009
12-hydroxypropyl-beta-cyclodextrinIBA
01/2009
1monomethoxypolyethyleneglycol- polylactide block copolymerIBA
10/2007
1Ethylene Glycol (Monoethylene Glycol)IBA
10/2007
1EnzymesIBA
07/2007
1Phosphatidylinositols (Phosphatidylinositol)IBA
07/2007
1PoisonsIBA
07/2007
1Antineoplastic Agents (Antineoplastics)IBA
07/2007
1Type I DNA Topoisomerases (Topoisomerase I)IBA
07/2007
1Serine (L-Serine)FDA Link
07/2007
1Threonine (L-Threonine)FDA Link
07/2007
1Alkylating AgentsIBA
12/2006
1IntegrinsIBA
11/2006

Therapy/Procedure

9Heterologous Transplantation (Xenotransplantation)
01/2015 - 01/2005
7Drug Therapy (Chemotherapy)
08/2015 - 01/2005
4Radiotherapy
05/2009 - 01/2005
1Castration
09/2013
1Blood Transfusion (Blood Transfusions)
06/2013
1Photochemotherapy (Photodynamic Therapy)
12/2011