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J Boos Selected Research

pegaspargase (Oncaspar)

9/2008Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study.
11/2005Asparagine concentration in plasma after 2,500 IU/m(2) PEG-asparaginase i.v. in children with acute lymphoblastic leukemia.
11/2003Lack of asparagine depletion in the cerebrospinal fluid after one intravenous dose of PEG-asparaginase: a window study at initial diagnosis of childhood ALL.
10/2002Drug monitoring of PEG-asparaginase treatment in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
11/2001Use of PEG-asparaginase in the treatment of patients with solid tumors.
8/2000Pegylated asparaginase (Oncaspar) in children with ALL: drug monitoring in reinduction according to the ALL/NHL-BFM 95 protocols.

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J Boos Research Topics

Disease

6Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2016 - 01/2001
4Neoplasms (Cancer)
05/2013 - 06/2001
3Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2016 - 08/2000
3Hypersensitivity (Allergy)
11/2005 - 08/2000
2Osteosarcoma (Osteogenic Sarcoma)
08/2006 - 06/2001
2Leukemia
02/2006 - 01/2001
1Rhabdoid Tumor (Rhabdoid Tumors)
05/2014
1Hematologic Neoplasms (Hematological Malignancy)
05/2013
1Heart Diseases (Heart Disease)
01/2012
1Renal Insufficiency (Renal Failure)
01/2012
1Body Weight (Weight, Body)
06/2009
1Hearing Loss (Hearing Impairment)
02/2008
1Neuroblastoma
08/2006
1Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
08/2006
1Anaplasia
05/2004
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
07/2002
1Mucositis
07/2002
1Sepsis (Septicemia)
07/2002
1Infection
07/2002
1Anaphylaxis (Anaphylactic Shock)
09/2001
1Neoplasm Metastasis (Metastasis)
06/2001
1Bone Diseases (Bone Disease)
06/2001
1Bone Resorption
06/2001
1Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell)
01/2001
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
01/2001

Drug/Important Bio-Agent (IBA)

6pegaspargase (Oncaspar)FDA Link
09/2008 - 08/2000
4Asparaginase (Elspar)FDA Link
09/2008 - 08/2000
2Cisplatin (Platino)FDA LinkGeneric
02/2008 - 08/2006
2AsparagineIBA
11/2005 - 11/2003
2Cytarabine (Cytosar-U)FDA LinkGeneric
07/2002 - 01/2001
1Itraconazole (Sporanox)FDA LinkGeneric
06/2009
1Carbon MonoxideIBA
06/2009
1LDL-Receptor Related Protein 2IBA
02/2008
1PlatinumIBA
08/2006
1calcium magnesium phosphateIBA
08/2006
1PotassiumIBA
08/2006
1CreatinineIBA
08/2006
1SodiumIBA
08/2006
1gemcitabineFDA Link
02/2006
1Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
11/2005
1Etoposide (VP 16)FDA LinkGeneric
05/2004
1IfosfamideFDA LinkGeneric
05/2004
1Carboplatin (JM8)FDA LinkGeneric
05/2004
1Biological Markers (Surrogate Marker)IBA
07/2002
1pamidronate (APD)FDA LinkGeneric
06/2001
1Clodronic Acid (Clodronate)IBA
06/2001
1Mevalonic Acid (Mevalonate)IBA
06/2001
1DiphosphonatesIBA
06/2001
1Arabinofuranosylcytosine TriphosphateIBA
01/2001
1triphosphoric acid (triphosphate)IBA
01/2001
1Hydroxyurea (Hydrea)FDA LinkGeneric
01/2001
1fludarabineIBA
01/2001
1CytosineIBA
01/2001
1Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
01/2001
1EnzymesIBA
08/2000

Therapy/Procedure

2Amputation
05/2013 - 01/2012
1Remission Induction
01/2016
1Drug Therapy (Chemotherapy)
05/2014
1Radiotherapy
05/2014