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Karen Blessing Selected Research

Sorbitol (Yal)

2/2014Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus.
8/2012Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation.
6/2011Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats.
1/2011Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats.
5/2010Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats.
8/2004Anticataract activity of analogs of a sorbitol dehydrogenase inhibitor.

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Karen Blessing Research Topics

Disease

7Cataract (Cataracts)
09/2014 - 08/2004
4Diabetic Retinopathy (Retinopathy, Diabetic)
02/2014 - 02/2007
2Hyperglycemia
01/2012 - 08/2004
2Periodontitis
06/2011 - 05/2010
2Alveolar Bone Loss
06/2011 - 05/2010
1Nephrogenic Fibrosing Dermopathy
05/2015
1Alzheimer Disease (Alzheimer's Disease)
01/2015
1Macular Degeneration (Age-Related Maculopathy)
01/2015
1Diabetes Mellitus
02/2014
1Corneal Edema
04/2007
1Retinal Neovascularization
04/2007
1Galactosemias (Galactosemia)
06/2002

Drug/Important Bio-Agent (IBA)

9Aldehyde Reductase (Aldose Reductase)IBA
02/2014 - 06/2002
6Sorbitol (Yal)FDA Link
02/2014 - 08/2004
5Streptozocin (Streptozotocin)FDA Link
09/2014 - 08/2004
5Retinaldehyde (Retinal)IBA
02/2014 - 06/2002
5Galactose (Galactopyranose)FDA LinkGeneric
04/2007 - 06/2002
3imirestatIBA
06/2011 - 05/2010
1Contrast MediaIBA
05/2015
1GadoliniumIBA
05/2015
1Amyloid (Amyloid Fibrils)IBA
01/2015
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2012
1GalactitolIBA
08/2012
1QuercetinIBA
06/2011
1tolrestatIBA
06/2011
1Xylose (D-Xylose)FDA Link
01/2011
1AntioxidantsIBA
01/2011
1Free RadicalsIBA
01/2011
1SuspensionsIBA
04/2007
1combretastatin A-4 (combretastatin A4)IBA
04/2007
1L-Iditol 2-Dehydrogenase (L Iditol 2 Dehydrogenase)IBA
08/2004
1polyolIBA
08/2004

Therapy/Procedure

2Injections
06/2011 - 05/2010
1Intraocular Injections
04/2007
1Topical Administration
10/2006
1Oral Administration
08/2004