Kaj Blennow Selected Research

Alzheimer Disease (Alzheimer's Disease)

09/2008	Association of complement factor H Y402H gene polymorphism with Alzheimer's disease.
05/2008	Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease.
05/2008	Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease.
04/2008	Targeted proteomics in Alzheimer's disease: focus on amyloid-beta.
01/2008	Core candidate neurochemical and imaging biomarkers of Alzheimer's disease.
11/2007	Intra-Individual Stability of CSF Biomarkers for Alzheimer's Disease over Two Years.
08/2007	Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease.
06/2007	Cerebrospinal fluid acetylcholinesterase changes after treatment with donepezil in patients with Alzheimer's disease.
05/2007	Longitudinal stability of CSF biomarkers in Alzheimer's disease.
01/2007	Effect of HMG-CoA reductase inhibitors on beta-amyloid peptide levels: implications for Alzheimer's disease.
12/2006	An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid.
06/2006	The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease.
03/2006	Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study.
09/2005	CSF biomarkers for Alzheimer's disease: use in early diagnosis and evaluation of drug treatment.
07/2005	Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease.
06/2005	Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.
04/2005	CSF biomarkers for mild cognitive impairment and early Alzheimer's disease.
01/2005	The link between cholesterol and Alzheimer's disease.
07/2004	Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease.
05/2004	Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease.
04/2004	Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism.
04/2004	Cerebrospinal fluid protein biomarkers for Alzheimer's disease.
03/2004	Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia.
01/2004	Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study.
07/2003	The transcobalamin (TC) codon 259 genetic polymorphism influences holo-TC concentration in cerebrospinal fluid from patients with Alzheimer disease.
06/2003	Advances in the detection of Alzheimer's disease-use of cerebrospinal fluid biomarkers.
01/2003	Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein.
08/2002	Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231.
07/2002	Beta-amyloid (Abeta) protein in cerebrospinal fluid as a biomarker for Alzheimer's disease.
03/2002	Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia.
01/2002	Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms.

Articles by Research Topic

Disease

31	Alzheimer Disease (Alzheimer's Disease) 09/2008 - 01/2002
6	Dementia (Dementias) 03/2007 - 01/2002
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2008 - 01/2002
4	Brain Injuries (Brain Injury) 05/2007 - 02/2003
3	Multiple Sclerosis 12/2007 - 03/2007
3	Schizophrenia (Dementia Praecox) 07/2004 - 01/2002
2	Open-Angle Glaucoma (Glaucoma, Open Angle) 06/2007 - 06/2007
2	Cataract (Cataracts) 01/2007 - 11/2005
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2004 - 01/2004
2	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2003 - 03/2002
1	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 05/2007
1	Down Syndrome (Down's Syndrome) 01/2007
1	Dissociative Disorders (Fugue) 01/2006
1	AIDS Dementia Complex 01/2006
1	Glioma (Gliomas) 01/2005
1	Hypercholesterolemia 03/2004

Drug/Important Bio-Agent (IBA)

14	Amyloid (Amyloid Fibrils)IBA 05/2008 - 01/2002
11	Biological Markers (Surrogate Marker)IBA 01/2008 - 06/2003
3	Apolipoproteins E (ApoE)IBA 10/2008 - 05/2004
2	PeptidesIBA 12/2007 - 07/2005
2	KinesinIBA 08/2007 - 01/2007
2	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 06/2007 - 11/2005
2	AcetylcholinesteraseIBA 06/2007 - 01/2003
2	Threonine (L-Threonine)FDA Link 01/2006 - 08/2002
2	tau Proteins (tau Protein)IBA 01/2006 - 08/2002
2	Proteins (Proteins, Gene)IBA 01/2005 - 12/2002
2	Amyloid beta-ProteinIBA 01/2004 - 02/2003
1	Complement Factor H (Factor H)IBA 09/2008
1	phenserineIBA 05/2008
1	Secretogranin IIIBA 12/2007
1	Chromogranin BIBA 12/2007
1	donepezil (Aricept)FDA LinkGeneric 06/2007
1	ApolipoproteinsIBA 06/2007
1	Glial Fibrillary Acidic ProteinIBA 05/2007
1	F2-Isoprostanes (F2 Isoprostanes)IBA 03/2007
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2007
1	Cathepsin DIBA 06/2006
1	CholesterolIBA 01/2005
1	TANDEMIBA 01/2005
1	3-nitrotyrosineIBA 07/2004
1	PhospholipidsIBA 07/2004
1	cholesterol 24-hydroxylase (CYP46)IBA 05/2004
1	Kallikreins (Kallikrein)IBA 03/2004
1	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 01/2004
1	EpitopesIBA 01/2004
1	Matrix MetalloproteinasesIBA 01/2004
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 10/2003
1	CytokinesIBA 08/2003
1	Codon (Codons)IBA 07/2003
1	Simvastatin (Zocor)FDA LinkGeneric 01/2003
1	ProteomeIBA 12/2002
1	GlycerophospholipidsIBA 05/2002
1	SynaptophysinIBA 05/2002
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2002
1	Transforming Growth Factor beta (TGF-beta)IBA 03/2002
1	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2002
1	Calcitonin Gene-Related PeptideIBA 01/2002
1	tiagabine (Gabitril)FDA Link 01/2002

Therapy/Procedure

2	Aftercare (After-Treatment) 06/2007 - 03/2004
1	Highly Active Antiretroviral Therapy (HAART) 01/2006