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David E Blask Selected Research

Melatonin

8/2015Doxorubicin resistance in breast cancer is driven by light at night-induced disruption of the circadian melatonin signal.
6/2015Melatonin: an inhibitor of breast cancer.
1/2015Daytime Blue Light Enhances the Nighttime Circadian Melatonin Inhibition of Human Prostate Cancer Growth.
8/2014Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer.
7/2014Regulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night.
4/2014Molecular deficiency (ies) in MT₁ melatonin signaling pathway underlies the melatonin-unresponsive phenotype in MDA-MB-231 human breast cancer cells.
1/2014Light exposure at night disrupts host/cancer circadian regulatory dynamics: impact on the Warburg effect, lipid signaling and tumor growth prevention.
11/2013Insulin and IGF1 enhance IL-17-induced chemokine expression through a GSK3B-dependent mechanism: a new target for melatonin's anti-inflammatory action.
2/2013Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth.
11/2012Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3β.
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David E Blask Research Topics

Disease

32Neoplasms (Cancer)
08/2015 - 02/2002
22Breast Neoplasms (Breast Cancer)
08/2015 - 07/2002
7Hepatocellular Carcinoma (Hepatoma)
05/2011 - 07/2002
3Genomic Instability
06/2015 - 01/2014
2Neoplasm Metastasis (Metastasis)
06/2015 - 11/2012
2Prostatic Neoplasms (Prostate Cancer)
01/2015 - 11/2013
2Adenocarcinoma
04/2012 - 07/2002
1Hyperglycemia
01/2014
1Hyperinsulinism (Hyperinsulinemia)
01/2014
1Obesity
11/2013
1Inflammation
11/2013
1Sarcoma (Soft Tissue Sarcoma)
08/2009
1Leiomyosarcoma
08/2009
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/2007
1Squamous Cell Neoplasms (Squamous Cell Cancer)
08/2007
1Lipoma (Lipomata)
01/2006

Drug/Important Bio-Agent (IBA)

29MelatoninIBA
08/2015 - 02/2002
21Linoleic Acid (Linoleate)IBA
01/2015 - 02/2002
1613-hydroxy-9,11-octadecadienoic acidIBA
04/2012 - 02/2002
8Phosphotransferases (Kinase)IBA
08/2015 - 08/2004
8ThymidineIBA
12/2009 - 06/2004
7Melatonin Receptors (Melatonin Receptor)IBA
10/2011 - 02/2002
6DNA (Deoxyribonucleic Acid)IBA
07/2014 - 06/2004
6Protein Kinases (Protein Kinase)IBA
05/2011 - 02/2002
4Messenger RNA (mRNA)IBA
06/2015 - 09/2011
4Estrogens (Estrogen)FDA Link
08/2014 - 09/2011
4HormonesIBA
01/2014 - 06/2004
4GTP-Binding Proteins (G-Protein)IBA
10/2007 - 04/2003
4Eicosapentaenoic AcidIBA
05/2006 - 04/2003
4Pertussis ToxinIBA
01/2006 - 06/2004
3MT1 Melatonin ReceptorIBA
06/2015 - 05/2011
3Carbon MonoxideIBA
04/2012 - 08/2009
3Steroid Receptors (Steroid Receptor)IBA
04/2011 - 06/2004
3Corn Oil (Oil, Corn)IBA
08/2009 - 06/2004
2Estrogen Receptor alphaIBA
08/2015 - 06/2015
2Tyrosine (L-Tyrosine)FDA Link
08/2015 - 08/2014
2Retroelements (Retrotransposon)IBA
06/2015 - 01/2014
2Glycogen Synthase KinasesIBA
11/2012 - 05/2011
2Glucose (Dextrose)FDA LinkGeneric
04/2012 - 05/2011
2Adenosine Monophosphate (AMP)IBA
10/2011 - 01/2006
2Proliferating Cell Nuclear Antigen (PCNA)IBA
05/2011 - 04/2011
2Dietary Fats (Ghee)IBA
10/2007 - 09/2005
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
07/2002 - 02/2002
1Transcription Factors (Transcription Factor)IBA
08/2015
1Doxorubicin (Adriamycin)FDA LinkGeneric
08/2015
1Estrogen Receptor Modulators (Antiestrogen)IBA
08/2014
1TamoxifenFDA LinkGeneric
08/2014
1Interleukin-6 (Interleukin 6)IBA
11/2013
1Insulin (Novolin)FDA Link
11/2013
1Interleukin-17 (Interleukin 27)IBA
11/2013
1p38 Mitogen-Activated Protein KinasesIBA
02/2013
1Urea (Carbamide)FDA LinkGeneric
02/2013
1Calmodulin (Calcium-Dependent Activator Protein)IBA
02/2013
1Protein-Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
11/2012
1Lactic AcidFDA LinkGeneric
04/2012
1Cholesterol Esters (Cholesteryl Esters)IBA
05/2011
1PhospholipidsIBA
05/2011
1Threonine (L-Threonine)FDA Link
05/2011
1Histones (Histone)IBA
05/2011
1Serine (L-Serine)FDA Link
05/2011
1Triglycerides (Triacylglycerol)IBA
05/2011
1Nonesterified Fatty Acids (NEFA)IBA
05/2011
1Insulin-Like Growth Factor I (IGF-1)IBA
04/2011
1CytokinesIBA
08/2009
1Linoleic AcidsIBA
08/2007
1Conjugated Linoleic AcidsIBA
08/2007
1olive oilIBA
01/2006
1Fatty Acids (Saturated Fatty Acids)IBA
09/2005
1Trans Fatty AcidsIBA
08/2004
1hydroxyoctadecadienoic acidIBA
08/2004
1Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
07/2002

Therapy/Procedure

25Heterologous Transplantation (Xenotransplantation)
08/2015 - 07/2002
1Drug Therapy (Chemotherapy)
08/2015
1Catheters
05/2006
1Radiotherapy
02/2002