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Kirby I Bland Selected Research

Hemorrhage

10/2008Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury.
10/2008Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels.
08/2008Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G.
08/2008Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis.
07/2008The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: Direct modulation of CINC-1 production by Kupffer cells.
06/2008Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1.
06/2008p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
04/2008Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage.
03/2008Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process.
03/2008Estrogen: a novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations.
03/2008Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhage.
01/200817beta-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-alpha.
10/2007Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation.
09/2007Estrogen receptor-alpha predominantly mediates the salutary effects of 17beta-estradiol on splenic macrophages following trauma-hemorrhage.
09/2007Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway.
07/200717 Beta-estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage.
06/2007Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage.
06/2007The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage.
06/2007The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhage.
05/2007Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage.
05/2007Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage.
03/200717Beta-estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage.
03/2007Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage.
02/2007Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway.
01/2007Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice.
01/200717beta-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage.
01/2007Young and middle-age associated differences in cytokeratin expression after bone fracture, tissue trauma, and hemorrhage.
11/2006Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice.
09/2006Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage.
09/2006Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: upregulation of heme oxygenase-1.
08/2006Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis.
08/200617 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alpha.
07/2006A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage.
06/2006Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage.
04/2006Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis.
03/2006Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expression.
01/2006Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1.
12/2005PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage.
08/2005Salutary effects of androstenediol on hepatic function after trauma-hemorrhage are mediated via peroxisome proliferators-activated receptor gamma.
07/2005Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase.
05/2005Transgenic prolactin-/- mice: effect of trauma-hemorrhage on splenocyte functions.
05/2005Gender differences in small intestinal perfusion following trauma hemorrhage: the role of endothelin-1.
02/2005Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase.
11/2004Mechanism of cardiac depression after trauma-hemorrhage: increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function.
09/2004Estradiol's effect on portal response to endothelin-1 after trauma-hemorrhage.
08/2004The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levels.
08/2004Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage.
06/2004Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage.
12/2003Upregulation of hepatic prolactin receptor gene expression by 17beta-estradiol following trauma-hemorrhage.
08/2003Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhage.
06/2003Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function.
04/2003Effect of estradiol administration on splanchnic perfusion after trauma-hemorrhage and sepsis.
03/2003Immunoprotection in proestrus females following trauma-hemorrhage: the pivotal role of estrogen receptors.
10/2002Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms.
04/2002Preservation of splenic immune functions by female sex hormones after trauma-hemorrhage.
01/2002Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsis.
01/2002Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis.

Articles by Research Topic

Disease

64Wounds and Injuries (Trauma)
10/2008 - 01/2002
57Hemorrhage
10/2008 - 01/2002
7Sepsis (Septicemia)
09/2007 - 01/2002
6Hemorrhagic Shock
01/2006 - 06/2003
5Neoplasms (Cancer)
06/2006 - 05/2003
3Breast Neoplasms (Breast Cancer)
05/2003 - 04/2002
2Bone Fractures (Bone Fracture)
01/2007 - 01/2007
2Anoxia (Hypoxia)
09/2006 - 05/2002
2Colorectal Neoplasms (Colorectal Cancer)
06/2005 - 11/2002
2Burns
05/2005 - 02/2005
1Hyperparathyroidism
06/2008
1Vitamin D Deficiency
06/2008
1Pancreatic Neoplasms (Pancreatic Cancer)
04/2008
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
02/2006
1Shock
01/2006
1Edema
05/2005
1Carcinoma (Carcinomatosis)
05/2003
1Cholangiocarcinoma
06/2002

Drug/Important Bio-Agent (IBA)

18Estrogens (Estrogen)FDA Link
10/2008 - 05/2002
8Estradiol (Estrace)FDA LinkGeneric
06/2008 - 01/2002
6AndrostenediolIBA
08/2006 - 08/2004
5Flutamide (Eulexin)FDA LinkGeneric
08/2008 - 07/2005
5Interleukin-6 (Interleukin 6)IBA
03/2007 - 08/2004
4p38 Mitogen-Activated Protein KinasesIBA
06/2008 - 09/2006
3Protein Kinases (Protein Kinase)IBA
04/2008 - 06/2007
3Estrogen Receptor alphaIBA
01/2008 - 08/2006
3Gonadal Steroid Hormones (Sex Hormones)IBA
09/2007 - 01/2002
3Peroxidase (Myeloperoxidase)IBA
09/2007 - 05/2005
3Endothelin-1 (Endothelin 1)IBA
01/2007 - 09/2004
3Estrogen Receptor betaIBA
09/2006 - 01/2006
3Estrogen ReceptorsIBA
12/2005 - 03/2003
2Heat-Shock Proteins (Heat-Shock Protein)IBA
03/2006 - 01/2006
2Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
07/2005 - 12/2003
2Prolactin Receptors (Prolactin Receptor)IBA
12/2003 - 05/2002
2UAB 30IBA
11/2003 - 08/2003
2TamoxifenFDA LinkGeneric
11/2003 - 06/2002
2ProgesteroneFDA LinkGeneric
07/2003 - 06/2003
1GlycogenIBA
10/2008
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
08/2008
1Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
08/2008
1Mitogen-Activated Protein KinasesIBA
07/2007
1Adenosine Triphosphate (ATP)IBA
05/2007
1Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
03/2007
1Keratins (Keratin)IBA
01/2007
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
01/2007
1Lidocaine (Xylocaine)FDA LinkGeneric
11/2006
1src-Family KinasesIBA
09/2006
1Heme Oxygenase-1IBA
09/2006
1PPAR gammaIBA
07/2006
1Biological Markers (Surrogate Marker)IBA
06/2006
1RetinoidsIBA
06/2006
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
02/2006
1Peroxisome ProliferatorsIBA
08/2005
1celecoxib (Celebrex)FDA Link
06/2005
1ProlactinIBA
05/2005
1Interleukin-18 (Interleukin 18)IBA
05/2005
1Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
02/2005
1OxygenIBA
02/2005
1SteroidsIBA
11/2004
1Interleukin-10 (Interleukin 10)IBA
06/2004
1Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
11/2003
1Dehydroepiandrosterone (DHEA)IBA
08/2003
1cetuximab (Erbitux)FDA Link
05/2003
1Proteins (Proteins, Gene)IBA
11/2002
1Nucleic AcidsIBA
11/2002
1NF-kappa B (NF-kB)IBA
10/2002
1Interferon-gamma (Interferon, gamma)IBA
06/2002

Therapy/Procedure

2Resuscitation
10/2008 - 06/2003
2Mastectomy (Mammectomy)
05/2003 - 06/2002
1Gastric Bypass (Roux-en-Y Gastric Bypass)
06/2008
1Heterologous Transplantation (Xenotransplantation)
04/2008
1Mammaplasty (Breast Reconstruction)
06/2002
1Drug Therapy (Chemotherapy)
04/2002