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Erwan Bezard Selected Research

Parkinson Disease (Parkinson's Disease)

11/2015M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.
9/2015Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia.
8/2015Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.
6/2015D1 dopamine receptor stimulation impairs striatal proteasome activity in Parkinsonism through 26S proteasome disassembly.
5/2015Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.
4/2015Could the serotonin theory give rise to a treatment for levodopa-induced dyskinesia in Parkinson's disease?
10/2014RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease.
8/2014Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives.
7/2014Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?
7/2014The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
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Erwan Bezard Research Topics

Disease

78Parkinson Disease (Parkinson's Disease)
11/2015 - 03/2003
53Dyskinesias (Dyskinesia)
11/2015 - 11/2003
16Parkinsonian Disorders (Parkinsonism)
09/2015 - 06/2004
5Neurodegenerative Diseases (Neurodegenerative Disease)
07/2014 - 09/2005
2Inflammation
08/2014 - 12/2009
2Disease Progression
07/2014 - 01/2010
2Dementia (Dementias)
07/2014 - 09/2012
2Alzheimer Disease (Alzheimer's Disease)
07/2014 - 04/2013
2Pain (Aches)
08/2011 - 03/2003
2Dystonia (Limb Dystonia)
09/2009 - 02/2004
2Chorea (Rheumatic Chorea)
07/2009 - 02/2004
1Animal Disease Models
11/2014
1Fatigue
08/2011
1Striatonigral Degeneration
12/2010
1MPTP Poisoning
12/2010
1Gambling (Pathological Gambling)
12/2009
1Bulimia (Binge Eating)
12/2009
1Impulse Control Disorders (Kleptomania)
12/2009
1Tremor (Tremors)
12/2009
1Sleep Disorders
10/2009

Drug/Important Bio-Agent (IBA)

57Levodopa (L Dopa)FDA LinkGeneric
11/2015 - 03/2003
31Dopamine (Intropin)FDA LinkGeneric
09/2015 - 04/2003
281- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
07/2014 - 11/2003
11Dopamine Receptors (Dopamine Receptor)IBA
06/2015 - 11/2004
6Serotonin (5 Hydroxytryptamine)IBA
09/2015 - 12/2008
5Oxidopamine (6 Hydroxydopamine)IBA
11/2012 - 03/2004
4Proteins (Proteins, Gene)IBA
10/2014 - 01/2006
4Electron Transport Complex IV (Cytochrome c Oxidase)IBA
12/2010 - 03/2004
4Messenger RNA (mRNA)IBA
09/2009 - 03/2004
4etiracetam (levetiracetam)FDA LinkGeneric
07/2004 - 11/2003
3SynucleinsIBA
08/2015 - 03/2014
3Phosphotransferases (Kinase)IBA
08/2014 - 01/2010
3Glutamate Receptors (Glutamate Receptor)IBA
05/2014 - 02/2010
2Proteasome Endopeptidase Complex (Proteasome)IBA
06/2015 - 01/2012
2GTP-Binding Proteins (G-Protein)IBA
05/2015 - 10/2014
2metabotropic glutamate receptor 5IBA
07/2014 - 09/2010
2Biological Markers (Surrogate Marker)IBA
07/2014 - 11/2010
2Amantadine (Aman)FDA LinkGeneric
05/2014 - 07/2004
2fenobamIBA
05/2014 - 09/2010
2Carbon MonoxideIBA
04/2013 - 12/2010
2Dopamine Agonists (Dopamine Agonist)IBA
01/2013 - 02/2008
2Dopamine D1 Receptors (Dopamine D1 Receptor)IBA
11/2012 - 01/2010
2Adenosine Triphosphatases (ATPase)IBA
09/2012 - 06/2012
2Protein Kinases (Protein Kinase)IBA
01/2010 - 04/2008
2N 0437FDA Link
02/2008 - 02/2007
2Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA
02/2008 - 05/2003
2ropinirole (Requip)FDA LinkGeneric
12/2007 - 11/2003
2polyphenolsIBA
12/2007 - 09/2005
2TeaIBA
12/2007 - 09/2005
2Deoxyglucose (2 Deoxy D glucose)IBA
03/2007 - 02/2005
2Minocycline (Cyclops)FDA LinkGeneric
09/2004 - 06/2004
2Dihydroxyphenylalanine (Dopa)IBA
07/2004 - 02/2004
1Muscarinic M4 ReceptorIBA
11/2015
1ATP dependent 26S protease (26S proteasome)IBA
06/2015
1Neurotransmitter Agents (Neurotransmitter)IBA
11/2014
1RGS ProteinsIBA
10/2014
1CalciumIBA
08/2014
1Calcium Channel Blockers (Blockers, Calcium Channel)IBA
08/2014
1Glucagon-Like Peptide 1 (GLP 1)IBA
07/2014
1HormonesIBA
07/2014
1alpha-SynucleinIBA
07/2014
1Insulin (Novolin)FDA Link
07/2014
1Insulin-Like Growth Factor I (IGF-1)IBA
07/2014
1Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA
07/2014
1N-Methylaspartate (NMDA)IBA
05/2014
1Tryptophan (L-Tryptophan)FDA Link
04/2014
1eltoprazineIBA
07/2013
1Simvastatin (Zocor)FDA LinkGeneric
04/2013
1Glutamic Acid (Glutamate)FDA Link
11/2012
1nociceptinIBA
11/2012
1NeuropeptidesIBA
11/2012
1gamma-Aminobutyric Acid (GABA)IBA
11/2012
1nociceptin receptorIBA
11/2012
1Parkinson disease 9IBA
09/2012
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2012
1Morphine (MS Contin)FDA LinkGeneric
08/2011
1ras-GRF1 (ras GRF1)IBA
12/2010
13-nitropropionic acidIBA
12/2010
1Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
11/2010
1MicroRNAs (MicroRNA)IBA
04/2010
1alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA
02/2010
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
01/2010
1Ribosomal Protein S6IBA
01/2010
1AMPA Receptors (AMPA Receptor)IBA
01/2010
1Neuroprotective AgentsIBA
01/2010
1Transcription Factors (Transcription Factor)IBA
09/2009
1Acquired CJDIBA
07/2009
1Isradipine (Dynacirc)FDA LinkGeneric
03/2009
15-HT1B Serotonin ReceptorIBA
12/2008
1Histones (Histone)IBA
07/2008
1Lovastatin (Mevacor)FDA LinkGeneric
04/2008
1Mitogen-Activated Protein Kinase 3IBA
04/2008
13-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)IBA
04/2008
1OxidoreductasesIBA
04/2008
1Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2007
1Opioid Peptides (Opioid Peptide)IBA
04/2007
1Opioid Receptors (Opioid Receptor)IBA
04/2007

Therapy/Procedure

2Drug Therapy (Chemotherapy)
04/2013 - 11/2010
2Denervation
03/2009 - 07/2005
1Deep Brain Stimulation
01/2011