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Anna Berkenblit Selected Research

temsirolimus

1/2014Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors.
1/2013Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer.
1/2012Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma.
7/2011Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors.
5/2011Drug-related pneumonitis in patients with advanced renal cell carcinoma treated with temsirolimus.
6/2010Phase I, pharmacokinetic study of temsirolimus administered orally to patients with advanced cancer.
1/2010Q-TWiST analysis of patients receiving temsirolimus or interferon alpha for treatment of advanced renal cell carcinoma.
12/2009Temsirolimus in mantle cell lymphoma and other non-Hodgkin lymphoma subtypes.
12/2009Clinical trial experience with temsirolimus in patients with advanced renal cell carcinoma.
8/2009Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha.
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Anna Berkenblit Research Topics

Disease

17Neoplasms (Cancer)
01/2014 - 06/2003
6Renal Cell Carcinoma (Grawitz Tumor)
10/2013 - 01/2009
4Neutropenia
12/2009 - 08/2005
3Breast Neoplasms (Breast Cancer)
01/2014 - 06/2010
3Asthenia
06/2010 - 08/2009
2Exanthema (Rash)
06/2010 - 12/2009
2Mucositis
06/2010 - 01/2007
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
12/2009 - 08/2009
2Anemia
12/2009 - 08/2009
2Thrombocytopenia (Thrombopenia)
12/2009 - 08/2009
2Fallopian Tube Neoplasms
11/2009 - 12/2004
2Stomach Neoplasms (Stomach Cancer)
09/2007 - 08/2005
2Ovarian Neoplasms (Ovarian Cancer)
01/2007 - 06/2005
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2014
1Lung Neoplasms (Lung Cancer)
01/2014
1Dysphonia (Spastic Dysphonia)
10/2013
1Diarrhea
10/2013
1Hypertension (High Blood Pressure)
10/2013
1Rhabdomyosarcoma
01/2012
1Glioma (Gliomas)
01/2012
1Neuroblastoma
01/2012
1Disease Progression
01/2012
1Pneumonia (Pneumonitis)
05/2011
1Non-Hodgkin Lymphoma (Lymphosarcoma)
12/2009
1Stomatitis
12/2009
1Anoxia (Hypoxia)
12/2009
1Hyperlipidemias (Hyperlipidemia)
12/2009
1Lymphoma (Lymphomas)
12/2009
1Hyperglycemia
12/2009
1Hypertriglyceridemia
11/2009
1Hypercholesterolemia
11/2009
1Hemorrhage
11/2009
1Dehydration (Water Stress)
11/2009
1Arthralgia (Joint Pain)
01/2007
1Kaposi Sarcoma (Kaposi's Sarcoma)
01/2007
1Carcinoma (Carcinomatosis)
08/2006
1Ascites
06/2005
1Pain (Aches)
06/2005
1Rupture
06/2005
1Neoplasm Metastasis (Metastasis)
01/2004

Drug/Important Bio-Agent (IBA)

12temsirolimusFDA Link
01/2014 - 01/2009
7Sirolimus (Rapamycin)FDA Link
01/2014 - 08/2009
4docetaxel (Taxotere)FDA Link
09/2007 - 06/2003
3Interferon-alpha (Interferon Alfa)FDA Link
01/2010 - 01/2009
3Carboplatin (JM8)FDA LinkGeneric
09/2007 - 06/2003
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2014 - 10/2013
2InterferonsIBA
05/2011 - 01/2010
2Biological Markers (Surrogate Marker)IBA
11/2010 - 10/2005
2Phosphotransferases (Kinase)IBA
11/2009 - 08/2009
2capecitabine (Xeloda)FDA Link
09/2007 - 08/2005
2PlatinumIBA
06/2005 - 12/2004
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
01/2014
1trastuzumab (Herceptin)FDA Link
01/2014
1N- (4- (3- chloro- 4- (2- pyridinylmethoxy)anilino)- 3- cyano- 7- ethoxy- 6- quinolyl)- 4- (dimethylamino)- 2- butenamideIBA
01/2014
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
01/2014
1Epidermal Growth Factor (EGF)IBA
01/2014
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
10/2013
1tivozanibIBA
10/2013
1sorafenib (BAY 43-9006)FDA Link
10/2013
1everolimusFDA Link
01/2013
1exemestane (Aromasin)FDA Link
01/2013
1Aromatase (CYP19)IBA
01/2013
1letrozole (Femara)FDA LinkGeneric
01/2013
1TransaminasesIBA
06/2010
1Proteins (Proteins, Gene)IBA
12/2009
14- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)IBA
11/2009
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
11/2009
1Lipase (Acid Lipase)FDA Link
11/2009
1CreatinineIBA
11/2009
1Paclitaxel (Taxol)FDA LinkGeneric
01/2007
1elesclomolIBA
01/2007
1Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
08/2006
1Plasminogen Activators (Plasminogen Activator)IBA
10/2005
1Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
10/2005
1AntigensIBA
10/2005
1taxaneIBA
06/2005
1temozolomide (Temodar)FDA LinkGeneric
01/2004
1Type I DNA Topoisomerases (Topoisomerase I)IBA
01/2004
1Topotecan (Hycamtin)FDA LinkGeneric
01/2004
1CytotoxinsIBA
01/2004
1gemcitabineFDA Link
06/2003

Therapy/Procedure

3Drug Therapy (Chemotherapy)
09/2007 - 01/2004
1Intravenous Infusions
07/2011
1Nephrectomy
12/2009
1Heterologous Transplantation (Xenotransplantation)
01/2007
1Laparotomy
06/2005
1Combination Drug Therapy (Combination Chemotherapy)
06/2005
1Radiotherapy
01/2004