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Barbara S Beckman Selected Research

3- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amide

2/2014Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival.
9/2013Targeting ovarian cancer and chemoresistance through selective inhibition of sphingosine kinase-2 with ABC294640.
7/2012Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
4/2011Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
11/2010Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.

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Barbara S Beckman Research Topics

Disease

20Breast Neoplasms (Breast Cancer)
01/2013 - 05/2004
15Neoplasms (Cancer)
02/2014 - 03/2005
7Carcinoma (Carcinomatosis)
01/2013 - 06/2004
3Ovarian Neoplasms (Ovarian Cancer)
09/2013 - 12/2006
3Neoplasm Metastasis (Metastasis)
01/2011 - 01/2008
3Anoxia (Hypoxia)
09/2009 - 12/2002
1Prostatic Neoplasms (Prostate Cancer)
02/2014
1Endometrial Neoplasms (Endometrial Cancer)
10/2012
1Weight Loss (Weight Reduction)
11/2010
1Hepatocellular Carcinoma (Hepatoma)
12/2002

Drug/Important Bio-Agent (IBA)

10Estrogens (Estrogen)FDA Link
10/2012 - 09/2006
6HormonesIBA
01/2013 - 09/2009
6sphingosine kinaseIBA
07/2012 - 11/2010
53- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amideIBA
02/2014 - 11/2010
5SphingosineIBA
02/2014 - 05/2004
3sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
09/2013 - 06/2011
3Protein Kinases (Protein Kinase)IBA
10/2012 - 12/2002
3Estrogen Receptor alphaIBA
01/2012 - 01/2010
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2012 - 03/2005
3Progesterone Receptors (Progesterone Receptor)IBA
06/2010 - 12/2006
2Protein Isoforms (Isoforms)IBA
07/2012 - 06/2011
2fulvestrant (Faslodex)FDA Link
01/2011 - 01/2010
2Carbon MonoxideIBA
06/2010 - 01/2007
2phytoalexinsIBA
01/2010 - 12/2006
2glyceollinIBA
01/2010 - 12/2006
2LuciferasesIBA
01/2007 - 12/2002
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
09/2006 - 12/2002
2NF-kappa B (NF-kB)IBA
06/2004 - 12/2002
1ceramide glucosyltransferaseIBA
02/2014
1Paclitaxel (Taxol)FDA LinkGeneric
09/2013
1Caspase 9IBA
09/2013
1CeramidesIBA
08/2013
1EnzymesIBA
08/2013
1Mitogen-Activated Protein KinasesIBA
01/2013
1Chalcone (Benzalacetophenone)IBA
10/2012
1JNK Mitogen-Activated Protein KinasesIBA
10/2012
1flavoneIBA
10/2012
1Phenobarbital (Luminal)FDA Link
07/2012
1Phenol (Carbolic Acid)FDA Link
06/2012
1Cytokine Receptors (Cytokine Receptor)IBA
01/2011
1tranilast (N 5')IBA
11/2010
14-hydroxytamoxifenIBA
01/2010
1Estrogen Receptor Modulators (Antiestrogen)IBA
01/2010
12,3-N-octanoylsphingosineIBA
09/2009
1lactate dehydrogenase 1 (LDH1)IBA
09/2009
1NucleotidesIBA
09/2009
1IsoflavonesIBA
05/2009
1ProteomeIBA
01/2008
1Phosphotransferases (Kinase)IBA
01/2007
1Complementary DNA (cDNA)IBA
01/2007
1integrin-linked kinaseIBA
01/2007
1Transcription Factors (Transcription Factor)IBA
01/2007
1TamoxifenFDA LinkGeneric
09/2006
1Estrogen Receptor betaIBA
09/2006
1FlavonoidsIBA
03/2005
1ApigeninIBA
03/2005
1Neuregulin-1 (Neuregulin 1)IBA
11/2004
1Proteins (Proteins, Gene)IBA
11/2004
1Caseins (Casein)FDA Link
11/2004
1histidine-rich proteinsIBA
11/2004
1CytokinesIBA
06/2004
12- octanoylamido- 4,6- octadecadiene- 1,3- diolIBA
05/2004
1ErythropoietinFDA Link
12/2002
1SB 203580IBA
12/2002
12- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA
12/2002
1OxygenIBA
12/2002
1Messenger RNA (mRNA)IBA
12/2002
1PD 98059IBA
12/2002

Therapy/Procedure

7Drug Therapy (Chemotherapy)
02/2014 - 01/2008
1Radiotherapy
08/2013
1Therapeutics
05/2010
1Chemoprevention
01/2010