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P J Barnes Selected Research

Chronic Obstructive Pulmonary Disease (COPD)

02/2008Outcomes for COPD pharmacological trials: from lung function to biomarkers.
09/2006Theophylline for COPD.
10/2005Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD.
07/2005Exhaled nitric oxide from lung periphery is increased in COPD.
06/2005Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma.
12/2004Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation.
11/2004Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease.
11/2003Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD.
09/2003Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways.
07/2003Exhaled leukotrienes and prostaglandins in COPD.
04/2003Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD.
07/2002Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD.
08/2001Exhaled carbon monoxide and nitric oxide in COPD.
09/2000Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers.
08/2000Exhaled ethane, a marker of lipid peroxidation, is elevated in chronic obstructive pulmonary disease.
02/2000Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic obstructive pulmonary disease.
02/2000Inhaled corticosteroids are not beneficial in chronic obstructive pulmonary disease.

Articles by Research Topic

Disease

26Asthma (Bronchial Asthma)
03/2007 - 01/2000
17Chronic Obstructive Pulmonary Disease (COPD)
02/2008 - 02/2000
5Cystic Fibrosis (Mucoviscidosis)
06/2001 - 02/2000
4Inflammation
12/2004 - 03/2000
3Lung Diseases (Lung Disease)
03/2005 - 01/2003
2Kartagener Syndrome (Primary Ciliary Dyskinesia)
01/2003 - 01/2003
1Respiratory Tract Infections (Respiratory Tract Infection)
12/2001
1Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis)
11/2000
1Bronchial Hyperreactivity
07/2000
1Airway Obstruction (Choking)
04/2000
1Rhinitis
01/2000

Drug/Important Bio-Agent (IBA)

10Nitric Oxide (Nitrogen Monoxide)FDA Link
07/2005 - 01/2000
6Carbon MonoxideIBA
01/2003 - 02/2000
4Theophylline (Theon)FDA LinkGeneric
09/2006 - 10/2000
38-epi-prostaglandin F2alphaIBA
04/2003 - 03/2000
3Budesonide (Pulmicort)FDA LinkGeneric
10/2002 - 06/2001
3Interleukin-5 (Interleukin 5)IBA
08/2002 - 10/2001
3EthaneIBA
10/2000 - 04/2000
2LeukotrienesIBA
07/2004 - 07/2003
2Interleukin-10 (Interleukin 10)IBA
11/2001 - 05/2000
2formoterol (Oxis)FDA Link
10/2001 - 06/2001
23-nitrotyrosineIBA
06/2001 - 10/2000
1Biological Markers (Surrogate Marker)IBA
02/2008
1EicosanoidsIBA
10/2005
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
10/2005
1Metalloproteases (Metalloproteinases)IBA
06/2005
1Histones (Histone)IBA
03/2005
1OxygenIBA
12/2004
1MucinsIBA
11/2004
1AdenosineFDA LinkGeneric
07/2004
1resveratrolIBA
11/2003
1Reactive Nitrogen SpeciesIBA
09/2003
1Xanthine OxidaseIBA
09/2003
1ProstaglandinsIBA
07/2003
1Leukotriene B4IBA
04/2003
1VitronectinIBA
03/2003
1Endothelin-1 (Endothelin 1)IBA
03/2003
1ChemokinesIBA
07/2002
1CCR3 ReceptorsIBA
06/2002
1GlucocorticoidsIBA
01/2002
1Leukotriene Antagonists (Leukotriene Receptor Antagonists)IBA
06/2001
1CytokinesIBA
01/2001
1anti-IgEIBA
11/2000
1Hydroxyurea (Hydrea)FDA LinkGeneric
11/2000
1SteroidsIBA
10/2000
1salmeterol (Serevent)FDA Link
09/2000
1Neurokinin-2 Receptors (Neurokinin 2 Receptor)IBA
07/2000
1Adrenergic beta-Agonists (beta-Adrenergic Agonists)IBA
07/2000
1TachykininsIBA
07/2000
1Vehicle Emissions (Emissions, Vehicle)IBA
07/2000
1Albuterol (Salbutamol)FDA LinkGeneric
05/2000
1Macrophage Inflammatory ProteinsIBA
05/2000
1Adrenal Cortex Hormones (Corticosteroids)IBA
02/2000
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
02/2000
1DNA (Deoxyribonucleic Acid)IBA
01/2000

Therapy/Procedure

1Nebulizers and Vaporizers (Inhaler)
03/2007