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Orit Bar-Am Selected Research

Monoamine Oxidase (MAO)

3/2015Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging.
8/2012Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.
4/2012Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment.
1/2012From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease.
3/2011Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim.
1/2011A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor.
1/2010Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.
2/2009The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats.
1/2008The neuroprotective mechanism of action of the multimodal drug ladostigil.
1/2007Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease.
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Orit Bar-Am Research Topics

Disease

18Alzheimer Disease (Alzheimer's Disease)
02/2014 - 10/2002
14Neurodegenerative Diseases (Neurodegenerative Disease)
09/2015 - 02/2005
11Neuroblastoma
04/2010 - 10/2002
7Parkinson Disease (Parkinson's Disease)
03/2015 - 12/2003
5Lewy Body Disease (Lewy Body Dementia)
01/2010 - 10/2006
4Dementia (Dementias)
04/2012 - 12/2006
4Pheochromocytoma
01/2012 - 09/2004
2Anoxia (Hypoxia)
02/2014 - 08/2012
2Basal Ganglia Diseases (Basal Ganglia Disease)
04/2012 - 01/2011
2Diabetes Mellitus
06/2010 - 11/2009
2Parkinsonian Disorders (Parkinsonism)
04/2010 - 11/2007
1Type 2 Diabetes Mellitus (MODY)
12/2014
1Hepatocellular Carcinoma (Hepatoma)
01/2013
1Memory Disorders (Memory Loss)
09/2012
1Amyloid Plaque
05/2012
1Gliosis
04/2012
1Heart Failure
07/2011
1Fibrosis (Cirrhosis)
07/2011
1Hypertrophy
07/2011
1Myocardial Infarction
06/2011
1Wounds and Injuries (Trauma)
06/2011
1Starvation
09/2008
1Neoplasms (Cancer)
09/2008
1Inflammation
08/2007

Drug/Important Bio-Agent (IBA)

22rasagiline (Azilect)FDA Link
09/2015 - 10/2002
17IronIBA
03/2015 - 02/2005
16Monoamine Oxidase (MAO)IBA
03/2015 - 12/2003
13(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamateIBA
04/2012 - 10/2002
9Cholinesterases (Cholinesterase)IBA
04/2012 - 10/2002
8Amyloid (Amyloid Fibrils)IBA
09/2012 - 10/2002
6N-propargylIBA
08/2012 - 05/2003
6propargylamineIBA
01/2010 - 08/2005
4Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA
09/2012 - 10/2005
4methyl carbamateIBA
04/2012 - 10/2002
4Reactive Oxygen Species (Oxygen Radicals)IBA
07/2011 - 09/2008
3Oxidopamine (6 Hydroxydopamine)IBA
03/2015 - 11/2007
3Insulin (Novolin)FDA Link
02/2014 - 11/2009
3Carbon MonoxideIBA
04/2012 - 12/2006
3(N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamateIBA
06/2004 - 10/2002
2Oxyquinoline (8 Hydroxyquinoline)FDA Link
08/2012 - 01/2010
2Chelating AgentsIBA
01/2012 - 02/2005
2Peroxynitrous Acid (Peroxynitrite)IBA
04/2010 - 11/2007
2rivastigmine (Exelon)FDA LinkGeneric
01/2010 - 10/2006
2Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
02/2009 - 09/2008
2CatalaseIBA
02/2009 - 09/2008
2Messenger RNA (mRNA)IBA
02/2009 - 08/2005
2Caspase 3 (Caspase-3)IBA
09/2008 - 01/2007
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
03/2015
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
03/2015
1Dopamine (Intropin)FDA LinkGeneric
03/2015
1Glucose (Dextrose)FDA LinkGeneric
02/2014
1Insulin ReceptorIBA
02/2014
1Fructose-Bisphosphate Aldolase (Aldolase)IBA
02/2014
1Ferritins (Ferritin)IBA
01/2013
1Presenilin-1IBA
09/2012
1Streptozocin (Streptozotocin)FDA Link
04/2012
1Acetylcholine (Acetylcholine Chloride)FDA Link
04/2012
1AcetylcholinesteraseIBA
01/2012
1Mitogen-Activated Protein Kinase 3IBA
01/2012
1Brain Natriuretic Peptide (Natrecor)FDA Link
07/2011
1lactacystinIBA
03/2011
1Levodopa (L Dopa)FDA LinkGeneric
11/2010
1Selegiline (E250)FDA LinkGeneric
01/2010
1Glutathione Reductase (Glutathione-Disulfide Reductase)IBA
02/2009
1EnzymesIBA
02/2009
1benzoquinone (quinone)IBA
02/2009
1PeroxiredoxinsIBA
02/2009
1NAD (NADH)IBA
02/2009
1Doxorubicin (Adriamycin)FDA LinkGeneric
09/2008
1inhibin beta A subunitIBA
11/2007
1activin AIBA
11/2007
13-morpholino-sydnonimine (SIN 1)IBA
11/2007
1epigallocatechin gallate (epigallocatechin-3-gallate)IBA
08/2007
1TeaIBA
08/2007
1polyphenolsIBA
08/2007
1FlavonoidsIBA
08/2007
1CurcuminIBA
08/2007
1Apoptosis Regulatory ProteinsIBA
01/2007
1AntioxidantsIBA
10/2005
1Brain-Derived Neurotrophic Factor (BDNF)IBA
08/2005
1Neuroprotective AgentsIBA
08/2005
1Staphylococcal Protein A (A, Protein)IBA
06/2004
1Phosphotransferases (Kinase)IBA
06/2004

Therapy/Procedure

1Therapeutics
03/2011