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Tamar Amit Selected Research

Monoamine Oxidase (MAO)

3/2015Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging.
9/2013Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators.
8/2012Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.
4/2012Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment.
1/2012From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease.
3/2011Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim.
1/2011A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor.
1/2011Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease.
1/2010Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.
1/2010Low dosage of rasagiline and epigallocatechin gallate synergistically restored the nigrostriatal axis in MPTP-induced parkinsonism.
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Tamar Amit Research Topics

Disease

28Neurodegenerative Diseases (Neurodegenerative Disease)
09/2015 - 10/2003
22Alzheimer Disease (Alzheimer's Disease)
09/2015 - 08/2002
20Parkinson Disease (Parkinson's Disease)
03/2015 - 08/2002
17Neuroblastoma
05/2012 - 08/2002
9Anoxia (Hypoxia)
02/2014 - 01/2005
9Dementia (Dementias)
04/2012 - 12/2006
6Inflammation
01/2012 - 09/2004
5Pheochromocytoma
01/2012 - 05/2003
5Parkinsonian Disorders (Parkinsonism)
04/2010 - 08/2002
5Lewy Body Disease (Lewy Body Dementia)
01/2010 - 10/2006
3Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2012 - 03/2004
3MPTP Poisoning
01/2010 - 01/2007
3Nervous System Diseases (Neurological Disorders)
10/2008 - 01/2008
2Memory Disorders (Memory Loss)
09/2015 - 09/2012
2Neoplasms (Cancer)
04/2013 - 09/2008
2Basal Ganglia Diseases (Basal Ganglia Disease)
04/2012 - 01/2011
2Diabetes Mellitus
06/2010 - 11/2009
2Craniocerebral Trauma (Head Injury)
04/2005 - 01/2005
2Ischemia
04/2005 - 01/2005
1Type 2 Diabetes Mellitus (MODY)
12/2014
1Hepatocellular Carcinoma (Hepatoma)
01/2013
1Amyloid Plaque
05/2012
1Gliosis
04/2012
1Heart Failure
07/2011
1Fibrosis (Cirrhosis)
07/2011
1Hypertrophy
07/2011
1Myocardial Infarction
06/2011
1Wounds and Injuries (Trauma)
06/2011
1Starvation
09/2008

Drug/Important Bio-Agent (IBA)

31rasagiline (Azilect)FDA Link
09/2015 - 10/2002
28IronIBA
09/2015 - 03/2004
22Monoamine Oxidase (MAO)IBA
03/2015 - 10/2003
14(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamateIBA
04/2012 - 10/2002
14TeaIBA
01/2011 - 08/2002
11Amyloid (Amyloid Fibrils)IBA
09/2012 - 08/2002
9Cholinesterases (Cholinesterase)IBA
04/2012 - 10/2002
9Reactive Oxygen Species (Oxygen Radicals)IBA
07/2011 - 03/2004
8Chelating AgentsIBA
09/2015 - 09/2004
7polyphenolsIBA
01/2012 - 03/2004
7propargylamineIBA
01/2010 - 04/2005
6N-propargylIBA
08/2012 - 05/2003
4Oxidopamine (6 Hydroxydopamine)IBA
03/2015 - 08/2002
4Proteins (Proteins, Gene)IBA
04/2013 - 08/2007
4methyl carbamateIBA
04/2012 - 10/2002
4(N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamateIBA
06/2004 - 10/2002
31- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
03/2015 - 10/2003
3Dopamine (Intropin)FDA LinkGeneric
03/2015 - 10/2003
3Insulin (Novolin)FDA Link
02/2014 - 11/2009
3Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA
09/2012 - 01/2007
3Carbon MonoxideIBA
04/2012 - 12/2006
3FlavonoidsIBA
01/2012 - 08/2007
3AntioxidantsIBA
01/2012 - 02/2006
3Levodopa (L Dopa)FDA LinkGeneric
11/2010 - 01/2005
3NeurotoxinsIBA
11/2009 - 01/2005
3Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
11/2009 - 09/2008
3Messenger RNA (mRNA)IBA
02/2009 - 08/2005
3Catechin (Z 7300)IBA
10/2008 - 01/2008
3Neuroprotective AgentsIBA
08/2005 - 09/2004
2Procollagen-Proline Dioxygenase (Prolyl Hydroxylase)IBA
01/2014 - 08/2007
2LithiumIBA
04/2013 - 05/2012
2Oxyquinoline (8 Hydroxyquinoline)FDA Link
08/2012 - 01/2010
2Free RadicalsIBA
01/2012 - 01/2011
2Peroxynitrous Acid (Peroxynitrite)IBA
04/2010 - 11/2007
2Selegiline (E250)FDA LinkGeneric
01/2010 - 11/2009
2epigallocatechin gallate (epigallocatechin-3-gallate)IBA
01/2010 - 08/2007
2rivastigmine (Exelon)FDA LinkGeneric
01/2010 - 10/2006
2CatalaseIBA
02/2009 - 09/2008
2Caspase 3 (Caspase-3)IBA
09/2008 - 01/2007
23-morpholino-sydnonimine (SIN 1)IBA
11/2007 - 10/2003
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
10/2007 - 01/2007
2Phosphotransferases (Kinase)IBA
06/2004 - 10/2003
2gallocatechol (epigallocatechin)IBA
03/2004 - 08/2002
2Conditioned Culture MediaIBA
05/2003 - 08/2002
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
03/2015
1Glucose (Dextrose)FDA LinkGeneric
02/2014
1Fructose-Bisphosphate Aldolase (Aldolase)IBA
02/2014
1Insulin ReceptorIBA
02/2014
1SynucleinsIBA
09/2013
1CyclinsIBA
04/2013
1Transcription Factors (Transcription Factor)IBA
04/2013
1Ferritins (Ferritin)IBA
01/2013
1Presenilin-1IBA
09/2012
1Streptozocin (Streptozotocin)FDA Link
04/2012
1Acetylcholine (Acetylcholine Chloride)FDA Link
04/2012
1Mitogen-Activated Protein Kinase 3IBA
01/2012
1AcetylcholinesteraseIBA
01/2012
1Brain Natriuretic Peptide (Natrecor)FDA Link
07/2011
1lactacystinIBA
03/2011
1Complement System Proteins (Complement)IBA
01/2010
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2009
1Biological Markers (Surrogate Marker)IBA
11/2009
1PeroxiredoxinsIBA
02/2009
1EnzymesIBA
02/2009
1Glutathione Reductase (Glutathione-Disulfide Reductase)IBA
02/2009
1benzoquinone (quinone)IBA
02/2009
1NAD (NADH)IBA
02/2009
1Doxorubicin (Adriamycin)FDA LinkGeneric
09/2008

Therapy/Procedure

1Therapeutics
03/2011
1Polypharmacy
01/2010
1Drug Therapy (Chemotherapy)
05/2008