Masayuki Amagai Selected Research

Pemphigus (Pemphigus Vulgaris)

07/2008	Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris.
06/2007	IgG autoantibodies directed against desmoglein 3 cause dissociation of keratinocytes in canine pemphigus vulgaris and paraneoplastic pemphigus.
12/2006	Synergistic pathogenic effects of combined mouse monoclonal anti-desmoglein 3 IgG antibodies on pemphigus vulgaris blister formation.
08/2006	Atypical pemphigus involving the esophagus with IgG antibodies to desmoglein 3 and IgA antibodies to desmoglein 1.
05/2006	[Loss of adhesive function of desmogleins in bullous diseases: pemphigus and impetigo]
03/2006	Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies.
01/2006	IgA/IgG pemphigus: a new atypical subset of pemphigus?
05/2005	In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris.
04/2005	Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display.
11/2004	Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome.
08/2004	Conformational epitope mapping of antibodies against desmoglein 3 in experimental murine pemphigus vulgaris.
05/2004	A case of herpetiform pemphigus with anti-desmoglein 3 IgG autoantibodies.
05/2004	IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model.
12/2003	Pathogenicity and epitope characteristics of anti-desmoglein-1 from pemphigus foliaceus patients expressing only IgG1 autoantibodies.
12/2003	Conformational epitope mapping and IgG subclass distribution of desmoglein 3 in paraneoplastic pemphigus.
09/2003	Cloning of canine desmoglein 3 and immunoreactivity of serum antibodies in human and canine pemphigus vulgaris with its extracellular domains.
08/2003	No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases.
04/2003	Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns.
02/2003	Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3.
10/2002	Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris.
03/2002	Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.

Articles by Research Topic

Disease

21	Pemphigus (Pemphigus Vulgaris) 07/2008 - 03/2002
2	Dissociative Disorders (Fugue) 06/2007 - 05/2005
2	Blister (Bulla) 12/2006 - 04/2003
2	Infection 10/2006 - 02/2003
2	Staphylococcal Scalded Skin Syndrome (Ritter's Disease) 09/2006 - 11/2004
1	Basal Cell Carcinoma (Rodent Ulcer) 09/2008
1	Neoplasms (Cancer) 09/2008
1	Atopic Dermatitis (Atopic Eczema) 08/2008
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 11/2006
1	Impetigo 05/2006
1	Bullous Pemphigoid (Pemphigoid) 01/2006
1	Benign Mucous Membrane Pemphigoid (Cicatricial Pemphigoid) 10/2005
1	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 10/2005
1	Psoriasis (Pustulosis Palmaris et Plantaris) 09/2003
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 08/2003

Drug/Important Bio-Agent (IBA)

14	Desmoglein 3IBA 06/2007 - 03/2002
12	Immunoglobulin G (IgG)IBA 06/2007 - 04/2003
9	AutoantibodiesIBA 06/2007 - 04/2003
6	DesmogleinsIBA 07/2008 - 02/2003
5	AntibodiesIBA 12/2006 - 10/2002
2	Desmoglein 1IBA 09/2006 - 08/2006
2	Immunoglobulin A (IgA)IBA 08/2006 - 01/2006
1	GTP-Binding Proteins (G-Protein)IBA 09/2008
1	filaggrinIBA 08/2008
1	p38 Mitogen-Activated Protein KinasesIBA 11/2006
1	Recombinant ProteinsIBA 01/2006
1	Keratins (Keratin)IBA 05/2004
1	Tacrolimus (Prograf)FDA Link 09/2003
1	Desmoglein 2IBA 08/2003

Therapy/Procedure

1	Stem Cell Transplantation 10/2005