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Rajesh Agarwal Selected Research

Carcinoma (Carcinomatosis)

09/2008Silibinin Impairs Constitutively Active TGFalpha-EGFR Autocrine Loop in Advanced Human Prostate Carcinoma Cells.
07/2008Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells.
12/2007Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft.
10/2007p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells.
07/2007Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3'-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.
07/2007Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells.
12/2006Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells.
07/2006Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.
11/2005Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells.
05/2005Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.
02/2005A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells.
09/2004Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells.
05/2004Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells.
02/2004Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells.
11/2003Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
09/2003Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death.
09/2003Inositol hexaphosphate inhibits constitutive activation of NF- kappa B in androgen-independent human prostate carcinoma DU145 cells.
09/2003Inhibition of NF-kappaB pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells.
05/2003Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells.
03/2003Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.
03/2003Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes.
11/2002Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release.
11/2002Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis.
06/2002Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels.
05/2002Inhibition of retinoblastoma protein (Rb) phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention.
03/2002The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells.

Articles by Research Topic

Disease

26Carcinoma (Carcinomatosis)
09/2008 - 03/2002
22Neoplasms (Cancer)
10/2008 - 03/2002
17Prostatic Neoplasms (Prostate Cancer)
07/2008 - 05/2002
3Adenocarcinoma
08/2008 - 11/2003
3Skin Neoplasms (Skin Cancer)
09/2005 - 08/2002
2Papilloma (Papillomatosis)
11/2006 - 12/2003
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2005 - 07/2004
1Neoplasm Metastasis (Metastasis)
08/2008
1Colorectal Neoplasms (Colorectal Cancer)
03/2008
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2008
1Hepatocellular Carcinoma (Hepatoma)
12/2005
1Transitional Cell Carcinoma
09/2004
1Glioma (Gliomas)
09/2003

Drug/Important Bio-Agent (IBA)

34silybin (silibinin)IBA
09/2008 - 03/2002
7Phytic Acid (Inositol Hexaphosphate)IBA
05/2008 - 03/2003
6SilymarinIBA
10/2008 - 03/2002
4Doxorubicin (Adriamycin)FDA LinkGeneric
12/2004 - 11/2002
3Gallic AcidIBA
05/2008 - 07/2006
3CyclinsIBA
09/2004 - 03/2003
3CaspasesIBA
07/2004 - 11/2002
3Insulin (Novolin)FDA Link
02/2004 - 06/2002
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
07/2008 - 08/2007
2CytotoxinsIBA
09/2007 - 02/2004
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2007 - 01/2004
2santalolIBA
09/2006 - 02/2005
2Cytochromes c (Cytochrome c)IBA
02/2005 - 11/2002
2Carboplatin (JM8)FDA LinkGeneric
02/2004 - 09/2003
2Cisplatin (Platino)FDA LinkGeneric
02/2004 - 09/2003
2NF-kappa B (NF-kB)IBA
09/2003 - 09/2003
1Transforming Growth Factor alpha (TGF-alpha)IBA
09/2008
1Tannins (Tannic Acid)FDA Link
07/2007
1procyanidin B2-3,3'-di-O-gallateIBA
07/2007
1isosilybin AIBA
07/2007
1Transcription Factors (Transcription Factor)IBA
06/2007
1Mitoxantrone (Novantrone)FDA LinkGeneric
05/2007
1silybin-phytosomeIBA
04/2007
1Caspase 2IBA
11/2006
1E2F Transcription FactorsIBA
08/2006
1FlavonoidsIBA
03/2006
1resveratrolIBA
11/2005
1FlavonolignansIBA
05/2005
1linarinIBA
04/2005
1acacetinIBA
04/2005
1decursinIBA
02/2005
1Caspase 3 (Caspase-3)IBA
09/2004
1Mitochondrial Proteins (Mitochondrial Protein)IBA
07/2004
1Protein Kinases (Protein Kinase)IBA
07/2004
1HormonesIBA
01/2004
1Messenger RNA (mRNA)IBA
12/2003
1Phosphotransferases (Kinase)IBA
11/2003
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
09/2003
1Epidermal Growth Factor (EGF)IBA
03/2003
1Serine (L-Serine)FDA Link
05/2002
1Retinoblastoma ProteinIBA
05/2002
1Mitogen-Activated Protein KinasesIBA
03/2002

Therapy/Procedure

4Chemoprevention
11/2007 - 06/2006
2Heterologous Transplantation (Xenotransplantation)
01/2008 - 12/2007