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Darío Acuña-Castroviejo Selected Research

Melatonin

9/2015Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice.
1/2015Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry.
1/2015Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis.
1/2014The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.
10/2011Synergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide.
7/2011Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy.
10/2010Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging.
9/2010The role of mitochondria in brain aging and the effects of melatonin.
4/2010Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy.
10/2009Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice.
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Darío Acuña-Castroviejo Research Topics

Disease

11Sepsis (Septicemia)
09/2015 - 05/2003
7Inflammation
09/2015 - 09/2006
4Neoplasms (Cancer)
01/2015 - 01/2005
3Neurodegenerative Diseases (Neurodegenerative Disease)
07/2014 - 09/2010
3Parkinson Disease (Parkinson's Disease)
10/2009 - 05/2003
3Endotoxemia
04/2007 - 05/2003
2Body Weight (Weight, Body)
07/2014 - 09/2006
2Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
07/2011 - 04/2010
2Colonic Neoplasms (Colon Cancer)
09/2007 - 10/2005
2Periodontal Diseases (Periodontal Disease)
06/2007 - 09/2006
1Ulcer
01/2015
1Mucositis
01/2015
1Stomatitis
01/2015
1Mitochondrial Diseases (Mitochondrial Disease)
07/2014
1Cerebellar Ataxia (Dysmetria)
07/2014
1Bipolar Disorder (Mania)
01/2012
1Anxiety Disorders (Anxiety Disorder)
01/2012
1Seasonal Affective Disorder
01/2012
1Depressive Disorder (Melancholia)
01/2012
1Muscular Dystrophies (Muscular Dystrophy)
07/2011
1Sickle Cell Anemia (Hemoglobin S Disease)
05/2011
1Oral Manifestations
10/2006
1Septic Shock (Toxic Shock Syndrome)
09/2006
1Shock
09/2006
1Hemolysis
09/2006
1Multiple Organ Failure (MODS)
09/2006
1Necrosis
10/2005
1Anoxia (Hypoxia)
07/2005
1Hypertension (High Blood Pressure)
03/2004
1Seizures (Seizure)
08/2003
1Nervous System Diseases (Neurological Disorders)
01/2002

Drug/Important Bio-Agent (IBA)

25MelatoninIBA
09/2015 - 05/2003
5Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
01/2014 - 03/2004
5Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2014 - 08/2003
3Glutathione (Reduced Glutathione)IBA
01/2014 - 09/2006
31- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
10/2009 - 05/2003
2EnzymesIBA
01/2014 - 10/2006
2Nitric Oxide Synthase (NO Synthase)IBA
04/2007 - 09/2006
2Adenosine Triphosphate (ATP)IBA
04/2007 - 10/2006
1Transcription Factors (Transcription Factor)IBA
09/2015
1malic acid (malate)IBA
01/2015
1RotenoneIBA
01/2015
1Succinic Acid (Succinate)IBA
01/2015
1Glutamic Acid (Glutamate)FDA Link
01/2015
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2015
1Leucine (L-Leucine)FDA Link
01/2015
1coenzyme Q10 (CoQ10)IBA
07/2014
1ubiquinol-10IBA
07/2014
1Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
01/2014
1Proteins (Proteins, Gene)IBA
01/2014
1NitritesIBA
01/2014
1Mitochondrial DNA (mtDNA)IBA
02/2012
1S 20098 (agomelatine)IBA
01/2012
1atorvastatin (Lipitor)FDA Link
10/2011
1GlobinsIBA
05/2011
1Sepharose (Agarose)IBA
05/2011
1CytokinesIBA
04/2010
1DystrophinIBA
04/2010
1Collagen Type I (Type I Collagen)IBA
06/2007
1Protein Isoforms (Isoforms)IBA
04/2007
1Adenosine Triphosphatases (ATPase)IBA
10/2006
1Glutathione Transferase (Glutathione S-Transferase)IBA
09/2006
1Superoxide DismutaseIBA
09/2006
1cyclopropapyrroloindoleIBA
09/2006
1Glutathione Reductase (Glutathione-Disulfide Reductase)IBA
09/2006
1Glutathione PeroxidaseIBA
09/2006
1Thiobarbituric Acid Reactive SubstancesIBA
09/2006
1Glutathione Disulfide (GSSG)FDA LinkGeneric
09/2006
1Free RadicalsIBA
09/2006
1CatalaseIBA
09/2006
1Peroxynitrous Acid (Peroxynitrite)IBA
09/2006
1Fluorescein-5-isothiocyanate (FITC)IBA
10/2005
1Propidium (Propidium Iodide)IBA
10/2005
1Annexin A5IBA
10/2005
1Cholecystokinin (Pancreozymin)IBA
10/2005
1Cholecystokinin Receptors (Cholecystokinin Receptor)IBA
10/2005
1IodineIBA
10/2005
1OxygenIBA
07/2005
1lacidipineIBA
03/2004
1Amino AcidsFDA Link
08/2003
1Pentylenetetrazole (Metrazol)IBA
08/2003
1Selegiline (E250)FDA LinkGeneric
05/2003
1Glutamate Receptors (Glutamate Receptor)IBA
01/2002
1N-Methylaspartate (NMDA)IBA
01/2002

Therapy/Procedure

4Ligation
01/2015 - 02/2006
1Radiotherapy
01/2015
1Drug Therapy (Chemotherapy)
01/2015
1Aftercare (After-Treatment)
10/2006