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Smith-Magenis Syndrome Summary

Description: Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and mental retardation. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.

Also Known As: Smith Magenis Syndrome; Syndrome, Smith-Magenis

Networked: 75 relevant articles (2 outcomes, 3 trials/studies) for this Disease

Key Drugs and Agents for Smith-Magenis Syndrome

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Drugs and Important Biological Agents (IBA) related to treatments:
  1. Melatonin : 1 outcome 1 study in 20 results : IBA
  2. Risperidone (Risperdal Consta) : 1 outcome in 1 result : FDA 35 Generic
  3. Carbon Monoxide : 1 study in 2 results : IBA
  4. retinoic acid receptor alpha : 1 study in 1 result : IBA
  5. Tretinoin (Retinoic Acid) : 14 results : FDA 27 Generic
  6. Potocki-Lupski syndrome : 9 results : IBA
  7. Hormones : 3 results : IBA
  8. Growth Hormone (Somatotropin) : 2 results : IBA
  9. DNA (Deoxyribonucleic Acid) : 2 results : IBA
  10. Carrier Proteins (Binding Protein) : 2 results : IBA
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Diseases Related to Smith-Magenis Syndrome

  1. Mental Retardation (Idiocy)
  2. Neoplasms (Cancer)
  3. Breast Neoplasms (Breast Cancer)
  4. Classical Lissencephalies and Subcortical Band Heterotopias
  5. Williams Syndrome (Williams-Beuren Syndrome)
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Key Therapies for Smith-Magenis Syndrome

Efficacy Chart >>
  1. Aftercare (After-Treatment) : 1 outcome in 1 result
  2. Ligation : 1 result
  3. Renal Dialysis (Hemodialysis) : 1 result
  4. Drug Therapy (Chemotherapy) : 1 result

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