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Frontotemporal Lobar Degeneration (Semantic Dementia) Summary

Description: Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.

Also Known As: Semantic Dementia; Degeneration, Frontotemporal Lobar; Dementia, Semantic; FTLD; Degenerations, Frontotemporal Lobar Show All >>

Networked: 1012 relevant articles (19 outcomes, 90 trials/studies) for this Disease

Key Drugs and Agents for Frontotemporal Lobar Degeneration

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. protein TDP-43 (TDP-43) : 7 outcomes 21 studies in 398 results : IBA
  2. Ubiquitin : 3 outcomes 5 studies in 290 results : IBA
  3. DNA-Binding Proteins (DNA Binding Protein) : 2 outcomes 9 studies in 261 results : IBA
  4. Biological Markers (Surrogate Marker) : 1 outcome 6 studies in 43 results : IBA
  5. Antibodies : 1 outcome 2 studies in 19 results : IBA
  6. Protein Isoforms (Isoforms) : 1 outcome 2 studies in 5 results : IBA
  7. Fluorodeoxyglucose F18 (Fludeoxyglucose F 18) : 1 outcome 1 study in 7 results : FDA 2
  8. pemetrexed (MTA) : 1 outcome 1 study in 2 results : FDA 3
  9. Fluvoxamine (Luvox) : 1 outcome 1 study in 1 result : FDA 18 Generic
  10. polyglutamine : 1 outcome in 7 results : IBA
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Diseases Related to Frontotemporal Lobar Degeneration

  1. Frontotemporal Lobar Degeneration (Semantic Dementia)
  2. Alzheimer Disease (Alzheimer's Disease)
  3. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
  4. Neurodegenerative Diseases (Neurodegenerative Disease)
  5. Dementia (Dementias)
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Key Therapies for Frontotemporal Lobar Degeneration

Efficacy Chart >>
  1. Therapeutics : 1 outcome 1 study in 5 results
  2. Aftercare (After-Treatment) : 1 outcome in 2 results
  3. Activities of Daily Living (ADL) : 1 study in 3 results
  4. Ligation : 1 study in 2 results
  5. Intravenous Injections : 1 study in 1 result
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