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Thrombotic Microangiopathies Summary

Description: Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.

Also Known As: Microangiopathies, Thrombotic; Microangiopathy, Thrombotic; Thrombotic Microangiopathy

Networked: 1277 relevant articles (31 outcomes, 46 trials/studies) for this Disease

Key Drugs and Agents for Thrombotic Microangiopathies

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. thymidine 5'-triphosphate (TTP) : 4 outcomes 6 studies in 187 results : IBA
  2. Complement System Proteins (Complement) : 2 outcomes 6 studies in 75 results : IBA
  3. von Willebrand Factor : 2 outcomes 2 studies in 52 results : IBA
  4. eculizumab : 2 outcomes 2 studies in 34 results : FDA 2
  5. Immunoglobulin G (IgG) : 2 outcomes 1 study in 8 results : IBA
  6. Atypical hemolytic uremic syndrome : 2 outcomes in 63 results : IBA
  7. Cyclosporine (Ciclosporin) : 2 outcomes in 44 results : FDA 20 Generic
  8. gemcitabine : 2 outcomes in 26 results : FDA 7
  9. imatinib (Gleevec) : 2 outcomes in 3 results : FDA 3
  10. Antibodies : 1 outcome 1 study in 31 results : IBA
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Diseases Related to Thrombotic Microangiopathies

  1. Neoplasms (Cancer)
  2. Thrombotic Thrombocytopenic Purpura
  3. Hemolytic-Uremic Syndrome
  4. Nephritis
  5. Pulmonary Hypertension (Ayerza Syndrome)
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Key Therapies for Thrombotic Microangiopathies

Efficacy Chart >>
  1. Plasma Exchange : 4 outcomes 3 studies in 67 results
  2. Transplants (Transplant) : 3 outcomes 9 studies in 171 results
  3. Aftercare (After-Treatment) : 2 outcomes 1 study in 8 results
  4. Transplantation (Transplant Recipients) : 1 outcome 4 studies in 109 results
  5. Homologous Transplantation (Allograft) : 1 outcome 1 study in 58 results
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