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Primary Graft Dysfunction Summary

Description: A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.

Also Known As: Dysfunction, Primary Graft; Graft Dysfunction, Primary

Networked: 347 relevant articles (10 outcomes, 23 trials/studies) for this Disease

Key Drugs and Agents for Primary Graft Dysfunction

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Prostaglandins D (PGD) : 2 outcomes 10 studies in 142 results : IBA
  2. Aprotinin (Trasylol) : 1 outcome 2 studies in 2 results : FDA 1
  3. Perfadex : 1 outcome in 1 result : IBA
  4. dicarboxydine (DCD) : 1 study in 10 results : IBA
  5. Cytokines : 1 study in 5 results : IBA
  6. Biological Markers (Surrogate Marker) : 1 study in 2 results : IBA
  7. Antibodies : 1 study in 2 results : IBA
  8. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor) : 1 study in 1 result : IBA
  9. Oxygen : 7 results : IBA
  10. Nitric Oxide (Nitrogen Monoxide) : 3 results : FDA 1
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Diseases Related to Primary Graft Dysfunction

  1. Reperfusion Injury
  2. Thrombosis (Thrombus)
  3. Brain Death (Brain Dead)
  4. Bronchiolitis Obliterans
  5. Lung Injury
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Key Therapies for Primary Graft Dysfunction

Efficacy Chart >>
  1. Lung Transplantation : 5 outcomes 11 studies in 148 results
  2. Transplants (Transplant) : 3 outcomes 4 studies in 68 results
  3. Extracorporeal Membrane Oxygenation (ECMO) : 2 outcomes in 27 results
  4. Transplantation (Transplant Recipients) : 1 outcome 1 study in 57 results
  5. Liver Transplantation : 1 outcome 1 study in 20 results
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