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Echinocandins Summary

Description: Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.

Also Known As: Aculeacins; Mulundocandins; Pneumocandins

Networked: 324 relevant articles (45 outcomes, 33 trials/studies) for this Bio-Agent

Key Diseases for which Echinocandins is Relevant

  1. Infection : 20 outcomes 15 studies in 161 results
  2. Invasive Candidiasis : 13 outcomes 8 studies in 57 results
  3. Aspergillosis : 10 outcomes 4 studies in 45 results
  4. Critical Illness (Critically Ill) : 6 outcomes 1 study in 24 results
  5. Candidemia : 5 outcomes 4 studies in 40 results
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Drugs Related to Echinocandins

  1. Amphotericin B (Amphotericin)
  2. voriconazole (Vfend)
  3. caspofungin (Cancidas)
  4. anidulafungin
  5. Azoles
  6. Triazoles
  7. Fluconazole (Zonal)
  8. micafungin (FK463)
  9. Antifungal Agents
  10. posaconazole
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Therapies Related to Echinocandins

  1. Salvage Therapy
  2. Transplants (Transplant)
  3. Catheters
  4. Transplantation (Transplant Recipients)
  5. Hematopoietic Stem Cell Transplantation
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