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rho-Associated Kinases Summary

Description: A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.

Also Known As: ROCK Protein Kinases; ROCK-I Protein Kinase; ROCK-II Protein Kinase; ROK Kinase; p160 rhoA-Binding Kinase ROKalpha Show All >>

Networked: 1279 relevant articles (71 outcomes, 207 trials/studies) for this Bio-Agent

Key Diseases for which rho-Associated Kinases is Relevant

  1. Pulmonary Hypertension (Ayerza Syndrome) : 9 outcomes 14 studies in 89 results
  2. Fibrosis (Cirrhosis) : 9 outcomes 9 studies in 55 results
  3. Hypertension (High Blood Pressure) : 6 outcomes 18 studies in 131 results
  4. Inflammation : 6 outcomes 7 studies in 74 results
  5. Cardiovascular Diseases (Cardiovascular Disease) : 4 outcomes 5 studies in 62 results
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Drugs Related to rho-Associated Kinases

  1. fasudil (AT 877)
  2. Y 27632
  3. Monocrotaline
  4. GTP Phosphohydrolases (GTPases)
  5. hydroxyfasudil
  6. Angiotensin II
  7. Phosphotransferases (Kinase)
  8. Glucose (Dextrose)
  9. Calcium
  10. Nitric Oxide (Nitrogen Monoxide)
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Therapies Related to rho-Associated Kinases

  1. Oral Administration
  2. Ligation
  3. Stents
  4. Airway Management
  5. Stem Cell Transplantation
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