Classical Lissencephalies and Subcortical Band Heterotopias Summary

42 relevant articles (1 outcomes, 1 trials/studies) found for this Disease

Description: Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)

Also Known As: Agyria-Pachygyria-Band Spectrum; Double Cortex Syndrome; Isolated Lissencephaly Sequence; Lissencephaly Syndrome, Miller-Dieker; Lissencephaly, Miller-Dieker Show All >>

Key Drugs and Agents for Classical Lissencephalies and Subcortical Band Heterotopias

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Drugs and Important Biological Agents (IBA) related to treatments:

lamotrigine (Lamictal) : 1 outcome in 1 result : FDA 17 Generic
Nonsense Codon (Nonsense Mutation) : 1 study in 1 result : IBA
Platelet Activating Factor : 8 results : IBA
Genetic Markers (Genetic Marker) : 3 results : IBA
1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase) : 2 results : IBA
Complementary DNA (cDNA) : 2 results : IBA
Staphylococcal Protein A (A, Protein) : 2 results : IBA
Dynein ATPase (Dynein) : 2 results : IBA
DNA (Deoxyribonucleic Acid) : 2 results : IBA
Carbon Monoxide : 2 results : IBA

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Diseases Related to Classical Lissencephalies and Subcortical Band Heterotopias

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Key Therapies for Classical Lissencephalies and Subcortical Band Heterotopias

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Anesthesia : 1 result