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Microsatellite Instability Summary

Description: The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR.

Also Known As: Replication Error Phenotype; Error Phenotype, Replication; Error Phenotypes, Replication; Instability, Microsatellite; Phenotype, Replication Error Show All >>

Networked: 3512 relevant articles (40 outcomes, 331 trials/studies) for this Disease

Key Drugs and Agents for Microsatellite Instability

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. N-methylsuccinimide : 30 outcomes 244 studies in 2672 results : IBA
  2. Fluorouracil (Carac) : 9 outcomes 6 studies in 53 results : FDA 33 Generic
  3. DNA (Deoxyribonucleic Acid) : 3 outcomes 31 studies in 444 results : IBA
  4. Calcibiotic Root Canal Sealer : 2 outcomes 7 studies in 125 results : IBA
  5. Thymidylate Synthase : 2 outcomes 5 studies in 25 results : IBA
  6. irinotecan (Camptosar) : 2 outcomes 3 studies in 9 results : FDA 19 Generic
  7. Leucovorin (Folinic Acid) : 2 outcomes in 5 results : FDA 6
  8. Proteins (Proteins, Gene) : 1 outcome 18 studies in 172 results : IBA
  9. Aspirin (Acetylsalicylic Acid) : 1 outcome 2 studies in 6 results : FDA 80 Generic
  10. Antigens : 1 outcome 1 study in 11 results : IBA
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Diseases Related to Microsatellite Instability

  1. Colorectal Neoplasms (Colorectal Cancer)
  2. Neoplasms (Cancer)
  3. Colonic Neoplasms (Colon Cancer)
  4. Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer)
  5. Carcinoma (Carcinomatosis)
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Key Therapies for Microsatellite Instability

Efficacy Chart >>
  1. Adjuvant Chemotherapy : 6 outcomes 7 studies in 38 results
  2. Drug Therapy (Chemotherapy) : 4 outcomes 11 studies in 73 results
  3. Transplantation (Transplant Recipients) : 1 outcome 1 study in 2 results
  4. Colectomy : 1 outcome in 5 results
  5. Neoadjuvant Therapy : 1 outcome in 3 results
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