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Death Domain Receptors Summary

Description: A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.

Also Known As: Receptors, Death Domain; Death Receptors; Receptors, DR Family; Receptors, Death Domain Family; DR Family Receptors Show All >>

Networked: 502 relevant articles (9 outcomes, 34 trials/studies) for this Bio-Agent

Key Diseases for which Death Domain Receptors is Relevant

  1. Neoplasms (Cancer) : 6 outcomes 13 studies in 253 results
  2. Neoplasm Metastasis (Metastasis) : 1 outcome 1 study in 4 results
  3. Liver Diseases (Liver Disease) : 1 outcome in 5 results
  4. Stomach Neoplasms (Stomach Cancer) : 1 outcome in 4 results
  5. Ovarian Neoplasms (Ovarian Cancer) : 1 outcome in 2 results
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Drugs Related to Death Domain Receptors

  1. Caspases
  2. TNF-Related Apoptosis-Inducing Ligand
  3. TNF-Related Apoptosis-Inducing Ligand Receptors
  4. NF-kappa B (NF-kB)
  5. Interferons
  6. bortezomib (Velcade)
  7. Indicators and Reagents (Reagents)
  8. Initiator Caspases
  9. Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)
  10. Calcitriol (Calcijex)
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Therapies Related to Death Domain Receptors

  1. Drug Therapy (Chemotherapy)
  2. Ligation
  3. Therapeutics
  4. Heterologous Transplantation (Xenotransplantation)
  5. Bariatric Surgery
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