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CADASIL Summary

Description: A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)

Also Known As: CADASILM; Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; Dementia, Hereditary Multi-Infarct Type; Dementia, Hereditary Multi Infarct Type

Networked: 354 relevant articles (8 outcomes, 36 trials/studies) for this Disease

Key Drugs and Agents for CADASIL

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. glucuronyl glucosamine glycan sulfate (Vessel) : 1 outcome 13 studies in 139 results : IBA
  2. CERE : 1 outcome 1 study in 1 result : IBA
  3. Acetazolamide (Diamox) : 1 outcome in 6 results : FDA 13 Generic
  4. KB 2796 (lomerizine) : 1 outcome in 2 results : IBA
  5. Fibrinolytic Agents (Antithrombotic Agents) : 1 outcome in 1 result : IBA
  6. Adenosine Triphosphate (ATP) : 1 outcome in 1 result : IBA
  7. atorvastatin (Lipitor) : 1 outcome in 1 result : FDA 2
  8. technetium Tc 99m bicisate (Neurolite) : 1 outcome in 1 result : FDA 1
  9. Retinaldehyde (Retinal) : 2 studies in 26 results : IBA
  10. Epidermal Growth Factor (EGF) : 2 studies in 24 results : IBA
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Diseases Related to CADASIL

  1. CADASIL
  2. Migraine Disorders (Migraine)
  3. Stroke (Strokes)
  4. Dementia (Dementias)
  5. Alzheimer Disease (Alzheimer's Disease)
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Key Therapies for CADASIL

Efficacy Chart >>
  1. Activities of Daily Living (ADL) : 1 study in 3 results
  2. Flowmeters : 1 study in 1 result
  3. Lasers (Laser) : 2 results
  4. Intravenous Injections : 2 results
  5. Anesthesia : 2 results
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