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Apparent Mineralocorticoid Excess Syndrome Summary

Description: A hereditary disease characterized by childhood onset HYPERTENSION, hypokalemic alkalosis, and low RENIN and ALDOSTERONE secretion. It results from a defect in the activity of the 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 enzyme which results in inadequate conversion of CORTISOL to CORTISONE. The build up of unprocessed cortisol to levels that stimulate MINERALOCORTICOID RECEPTORS creates the appearance of having excessive MINERALOCORTICOIDS.

Also Known As: Mineralocorticoid Excess Syndrome, Apparent

Networked: 27 relevant articles (0 outcomes, 3 trials/studies) for this Disease

Key Drugs and Agents for Apparent Mineralocorticoid Excess Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Epithelial Sodium Channel : 2 studies in 4 results : IBA
  2. Mineralocorticoids : 2 studies in 3 results : IBA
  3. 11-beta-Hydroxysteroid Dehydrogenase Type 2 (11 beta-Hydroxysteroid Dehydrogenase Type 2) : 1 study in 4 results : IBA
  4. Cortisone : 1 study in 4 results : IBA
  5. Hydrocortisone (Cortisol) : 8 results : FDA 176 Generic
  6. methylamphotericin B (AME) : 5 results : IBA
  7. Renin : 4 results : IBA
  8. 11-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase) : 2 results : IBA
  9. Glycyrrhizic Acid (Glycyrrhizin) : 2 results : IBA
  10. Tetrahydrocortisone : 2 results : IBA
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Diseases Related to Apparent Mineralocorticoid Excess Syndrome

  1. Hyperaldosteronism (Conn Syndrome)
  2. Liddle Syndrome
  3. Pseudohypoaldosteronism
  4. Hypertension (High Blood Pressure)
  5. Hypokalemia
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Key Therapies for Apparent Mineralocorticoid Excess Syndrome

Efficacy Chart >>
  1. Kidney Transplantation : 1 result

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