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Alexander Disease (Alexander's Disease) Summary

Description: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.

Also Known As: Alexander's Disease; Alexanders Disease

Networked: 153 relevant articles (2 outcomes, 8 trials/studies) for this Disease

Key Drugs and Agents for Alexander Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Glial Fibrillary Acidic Protein : 1 outcome 5 studies in 91 results : IBA
  2. Proteins (Proteins, Gene) : 1 outcome 1 study in 5 results : IBA
  3. Proteasome Endopeptidase Complex (Proteasome) : 1 outcome 1 study in 4 results : IBA
  4. Sirolimus (Rapamycin) : 1 outcome 1 study in 1 result : FDA 2
  5. Crystallins (Crystallin) : 1 study in 9 results : IBA
  6. Heat-Shock Proteins (Heat-Shock Protein) : 1 study in 6 results : IBA
  7. Antibodies : 1 study in 3 results : IBA
  8. Peroxidase (Myeloperoxidase) : 1 study in 1 result : IBA
  9. Lysine (L-Lysine) : 1 study in 1 result : FDA 30
  10. Immunoglobulins (Immunoglobulin) : 1 study in 1 result : IBA
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Diseases Related to Alexander Disease

  1. Neurodegenerative Diseases (Neurodegenerative Disease)
  2. Brain Ischemia (Cerebral Ischemia)
  3. Multiple Sclerosis
  4. Leukoencephalopathies
  5. Nervous System Diseases (Neurological Disorders)
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Key Therapies for Alexander Disease

Efficacy Chart >>
  1. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 1 outcome in 1 result
  2. Ventriculoperitoneal Shunt : 1 result
  3. Transplantation (Transplant Recipients) : 1 result

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