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RNA-Binding Protein FUS Summary

Description: A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.

Also Known As: FUS Protein; Fusion Protein in Myxoid Liposarcoma; POMp75 Protein; TLS Protein; Translocated in Liposarcoma Protein Show All >>

Networked: 56 relevant articles (0 outcomes, 3 trials/studies) for this Bio-Agent

Key Diseases for which RNA-Binding Protein FUS is Relevant

  1. Sarcoma (Soft Tissue Sarcoma) : 2 studies in 31 results
  2. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) : 1 study in 24 results
  3. Frontotemporal Lobar Degeneration (Semantic Dementia) : 1 study in 13 results
  4. Cytomegalovirus Infections (Inclusion Disease) : 1 study in 2 results
  5. Neurodegenerative Diseases (Neurodegenerative Disease) : 10 results
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Drugs Related to RNA-Binding Protein FUS

  1. Mutant Proteins (Protein, Mutant)
  2. Ubiquitin
  3. RNA (Ribonucleic Acid)
  4. DNA-Binding Proteins (DNA Binding Protein)
  5. RNA-Binding Protein EWS
  6. Messenger RNA (mRNA)
  7. Proteins (Proteins, Gene)
  8. DNA (Deoxyribonucleic Acid)
  9. polyglutamine
  10. Transcription Factor CHOP
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Therapies Related to RNA-Binding Protein FUS


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