Search Login Register

Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) Summary

Description: A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))

Also Known As: Leber's Hereditary Optic Neuropathy; Leber Optic Atrophy; Optic Atrophy, Hereditary, Leber; Leber Hereditary Optic Neuropathy; Leber Optic Atrophy and Dystonia Show All >>

Networked: 605 relevant articles (7 outcomes, 41 trials/studies) for this Disease

Key Drugs and Agents for Leber Hereditary Optic Atrophy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. idebenone : 5 outcomes 3 studies in 15 results : IBA
  2. Glutathione (Reduced Glutathione) : 1 outcome in 2 results : IBA
  3. Antioxidants : 1 outcome in 2 results : IBA
  4. Mitochondrial DNA (mtDNA) : 27 studies in 433 results : IBA
  5. Retinaldehyde (Retinal) : 4 studies in 24 results : IBA
  6. Phosphorus : 2 studies in 4 results : IBA
  7. Mitochondrial encephalopathy : 1 study in 11 results : IBA
  8. NADH Dehydrogenase : 1 study in 9 results : IBA
  9. NAD (NADH) : 1 study in 4 results : IBA
  10. Ubiquinone : 1 study in 3 results : IBA
Show All >>

Diseases Related to Leber Hereditary Optic Atrophy

  1. Friedreich Ataxia (Friedreich's Ataxia)
  2. Optic Nerve Diseases (Optic Neuropathy)
  3. Stroke (Strokes)
  4. Lactic Acidosis
  5. Multiple Sclerosis
Show All >>

Key Therapies for Leber Hereditary Optic Atrophy

Efficacy Chart >>
  1. Plasma Exchange : 1 outcome in 1 result
  2. Lasers (Laser) : 1 study in 3 results
  3. Intravitreal Injections : 1 study in 1 result
  4. Drug Therapy (Chemotherapy) : 2 results
  5. Bariatric Surgery : 1 result
Show All >>

CureHunter Inc. provides medical information and specifically does NOT provide medical advice.
© Copyright 2003-2016 CureHunter Inc., MeSH copyright NLM, Journal Articles copyright original owners.