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Lewy Body Disease (Lewy Body Dementia) Summary

Description: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)

Also Known As: Lewy Body Dementia; Cortical Lewy Body Disease; Lewy Body Disease, Cortical; Lewy Body Disease, Diffuse; Lewy Body Type Senile Dementia Show All >>

Networked: 480 relevant articles (15 outcomes, 51 trials/studies) for this Disease

Key Drugs and Agents for Lewy Body Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. rivastigmine (Exelon) : 4 outcomes 5 studies in 13 results : FDA 7 Generic
  2. donepezil (Aricept) : 2 outcomes 2 studies in 8 results : FDA 18 Generic
  3. Levodopa (L Dopa) : 2 outcomes in 12 results : FDA 31 Generic
  4. alpha-Synuclein : 1 outcome 7 studies in 104 results : IBA
  5. Cholinesterase Inhibitors (Anticholinesterases) : 1 outcome 3 studies in 18 results : IBA
  6. beta-Synuclein : 1 outcome 1 study in 3 results : IBA
  7. Yi-Gan San : 1 outcome 1 study in 1 result : IBA
  8. 2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B) : 1 outcome 1 study in 1 result : IBA
  9. Memantine (Namenda) : 1 outcome in 6 results : FDA 12
  10. 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP) : 1 outcome in 2 results : IBA
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Diseases Related to Lewy Body Disease

  1. Dementia (Dementias)
  2. Parkinson Disease (Parkinson's Disease)
  3. Alzheimer Disease (Alzheimer's Disease)
  4. Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
  5. Neurodegenerative Diseases (Neurodegenerative Disease)
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Key Therapies for Lewy Body Disease

Efficacy Chart >>
  1. Aftercare (After-Treatment) : 1 outcome in 1 result
  2. Sympathectomy (Sympathectomies) : 5 results
  3. Therapeutics : 1 result
  4. Parenteral Nutrition : 1 result
  5. Home Nursing (Nursing, Home) : 1 result
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