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Striatonigral Degeneration Summary

Description: A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)

Also Known As: Striatonigral Atrophy; Atrophies, Striatonigral; Atrophy, Striatonigral; Degeneration, Striatonigral; Striatonigral Atrophies Show All >>

Networked: 86 relevant articles (2 outcomes, 16 trials/studies) for this Disease

Key Drugs and Agents for Striatonigral Degeneration

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Levodopa (L Dopa) : 1 outcome 5 studies in 22 results : FDA 31 Generic
  2. Dopamine (Intropin) : 1 outcome 2 studies in 6 results : FDA 36 Generic
  3. Homovanillic Acid : 1 outcome 1 study in 1 result : IBA
  4. Calcineurin : 2 studies in 5 results : IBA
  5. Quinolinic Acid : 1 study in 5 results : IBA
  6. Silver : 1 study in 4 results : IBA
  7. Oxidopamine (6 Hydroxydopamine) : 1 study in 3 results : IBA
  8. Substance P : 1 study in 2 results : IBA
  9. Glucose (Dextrose) : 1 study in 2 results : FDA 175 Generic
  10. Carbon Monoxide : 1 study in 2 results : IBA
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Diseases Related to Striatonigral Degeneration

  1. Parkinson Disease (Parkinson's Disease)
  2. Multiple System Atrophy
  3. Parkinsonian Disorders (Parkinsonism)
  4. Olivopontocerebellar Atrophies (Olivopontocerebellar Atrophy)
  5. Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
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Key Therapies for Striatonigral Degeneration

Efficacy Chart >>
  1. Transplantation (Transplant Recipients) : 1 outcome in 1 result
  2. Transplants (Transplant) : 1 study in 4 results
  3. Homologous Transplantation (Allograft) : 2 results
  4. Pallidotomy : 1 result

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