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Pick Disease of the Brain (Pick's Disease) Summary

Description: A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)

Also Known As: Pick's Disease; Brain Atrophy, Circumscribed Lobar; Pick Disease; Picks Disease of Brain; Atrophies, Lobar (Brain) Show All >>

Networked: 286 relevant articles (5 outcomes, 23 trials/studies) for this Disease

Key Drugs and Agents for Pick Disease of the Brain

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Amyloid (Amyloid Fibrils) : 1 outcome in 11 results : IBA
  2. alpha-Crystallin B Chain : 1 outcome in 4 results : IBA
  3. Calcium : 1 outcome in 3 results : IBA
  4. Glucose (Dextrose) : 1 outcome in 2 results : FDA 175 Generic
  5. Neuropeptides : 1 outcome in 1 result : IBA
  6. Edetic Acid (EDTA) : 1 outcome in 1 result : FDA 1
  7. rivastigmine (Exelon) : 1 outcome in 1 result : FDA 7 Generic
  8. tau Proteins (tau Protein) : 3 studies in 47 results : IBA
  9. Protein Isoforms (Isoforms) : 3 studies in 22 results : IBA
  10. Apolipoproteins E (ApoE) : 2 studies in 10 results : IBA
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Diseases Related to Pick Disease of the Brain

  1. Alzheimer Disease (Alzheimer's Disease)
  2. Frontotemporal Lobar Degeneration (Semantic Dementia)
  3. Frontotemporal Dementia
  4. Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
  5. Dementia (Dementias)
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Key Therapies for Pick Disease of the Brain

Efficacy Chart >>
  1. Lasers (Laser) : 1 study in 3 results
  2. Nursing Care : 1 study in 1 result
  3. Pericardiectomy : 1 result
  4. Home Nursing (Nursing, Home) : 1 result
  5. Drug Therapy (Chemotherapy) : 1 result

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