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Isaacs Syndrome (Neuromyotonia) Summary

Description: A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)

Also Known As: Neuromyotonia; Isaacs-Mertens Syndrome; Pseudomyotonia; Acquired Neuromyotonia; Continuous Muscle Activity Syndrome Show All >>

Networked: 194 relevant articles (8 outcomes, 4 trials/studies) for this Disease

Key Drugs and Agents for Isaacs Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Antibodies : 2 outcomes 2 studies in 66 results : IBA
  2. Carbamazepine (Tegretol) : 2 outcomes 2 studies in 13 results : FDA 24 Generic
  3. Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel) : 1 outcome in 56 results : IBA
  4. Autoantibodies : 1 outcome in 24 results : IBA
  5. Immunoglobulin G (IgG) : 1 outcome in 4 results : IBA
  6. Methylprednisolone : 1 outcome in 2 results : FDA 18 Generic
  7. Anticonvulsants (Antiepileptic Drugs) : 1 outcome in 2 results : IBA
  8. gabapentin (Neurontin) : 1 outcome in 2 results : FDA 37 Generic
  9. Cyclophosphamide (Cytoxan) : 1 outcome in 1 result : FDA 10 Generic
  10. Potassium Channels (Potassium Channel) : 1 study in 20 results : IBA
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Diseases Related to Isaacs Syndrome

  1. Isaacs Syndrome (Neuromyotonia)
  2. Thymoma (Thymic Carcinoma)
  3. Constipation
  4. Myokymia
  5. Myoclonus (Nocturnal Myoclonus)
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Key Therapies for Isaacs Syndrome

Efficacy Chart >>
  1. Plasmapheresis : 2 outcomes in 5 results
  2. Plasma Exchange : 9 results
  3. Anesthesia : 4 results
  4. Thymectomy : 3 results
  5. Radiotherapy : 3 results
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