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Guillain-Barre Syndrome Summary

Description: An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)

Also Known As: Acute Inflammatory Demyelinating Polyneuropathy; Acute Inflammatory Polyradiculoneuropathy; Demyelinating Polyradiculoneuropathy, Acute Inflammatory; Guillaine-Barre Syndrome; Inflammatory Demyelinating Polyradiculoneuropathy, Acute Show All >>

Networked: 417 relevant articles (15 outcomes, 38 trials/studies) for this Disease

Key Drugs and Agents for Guillain-Barre Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Intravenous Immunoglobulins (IVIG) : 4 outcomes 2 studies in 23 results : FDA 1
  2. Immunoglobulins (Immunoglobulin) : 3 outcomes 2 studies in 23 results : IBA
  3. Adrenal Cortex Hormones (Corticosteroids) : 1 outcome 2 studies in 7 results : IBA
  4. Prednisolone (Predate) : 1 outcome in 2 results : FDA 55 Generic
  5. Cytostatic Agents : 1 outcome in 1 result : IBA
  6. Cyclophosphamide (Cytoxan) : 1 outcome in 1 result : FDA 10 Generic
  7. Cholinesterase Inhibitors (Anticholinesterases) : 1 outcome in 1 result : IBA
  8. Azathioprine (Imuran) : 1 outcome in 1 result : FDA 7 Generic
  9. Analgesics (Analgesic Drugs) : 1 outcome in 1 result : IBA
  10. Hashimoto's encephalitis : 1 outcome in 1 result : IBA
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Diseases Related to Guillain-Barre Syndrome

  1. Multiple Sclerosis
  2. Polyneuropathies (Polyneuropathy)
  3. Myasthenia Gravis
  4. Demyelinating Diseases (Demyelinating Disease)
  5. Systemic Lupus Erythematosus (Libman-Sacks Disease)
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Key Therapies for Guillain-Barre Syndrome

Efficacy Chart >>
  1. Plasmapheresis : 3 outcomes 3 studies in 23 results
  2. Immunotherapy : 2 outcomes in 3 results
  3. Plasma Exchange : 1 outcome 5 studies in 25 results
  4. Blood Component Removal (Apheresis) : 1 outcome 1 study in 3 results
  5. Immunomodulation : 1 outcome in 1 result
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