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MPTP Poisoning Summary

Description: A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

Also Known As: MPTP-Induced Degeneration of the Striatum; MPTP-Induced Parkinsonism; Neurotoxicity Syndrome, MPTP; Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP Induced Degeneration of the Striatum; MPTP Induced Parkinsonism; MPTP Neurotoxicity Syndromes; Neurotoxicity Syndromes, MPTP; Parkinsonism, MPTP-Induced; Poisoning, MPTP; MPTP Neurotoxicity Syndrome

Networked: 143 relevant articles (8 outcomes, 30 trials/studies) for this Disease

Key Drugs and Agents for MPTP Poisoning

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP) : 1 outcome 13 studies in 44 results : IBA
  2. Dihydroxyphenylalanine (Dopa) : 1 outcome in 2 results : IBA
  3. resveratrol : 1 outcome in 2 results : IBA
  4. Proto-Oncogene Proteins c-akt (Protein Kinase B) : 1 outcome in 1 result : IBA
  5. Nicotine : 1 outcome in 1 result : FDA 9
  6. Liposomes (Liposome) : 1 outcome in 1 result : IBA
  7. Caffeine (No Doz) : 1 outcome in 1 result : FDA 88 Generic
  8. ML 23 : 1 outcome in 1 result : IBA
  9. polylactic acid-polyglycolic acid copolymer (PLGA) : 1 outcome in 1 result : IBA
  10. poly(lactide) (polylactide) : 1 outcome in 1 result : IBA
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Diseases Related to MPTP Poisoning

  1. Parkinson Disease (Parkinson's Disease)
  2. Parkinsonian Disorders (Parkinsonism)
  3. Dyskinesias (Dyskinesia)
  4. Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
  5. Striatonigral Degeneration
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Key Therapies for MPTP Poisoning

Efficacy Chart >>
  1. Deep Brain Stimulation : 1 outcome 1 study in 1 result
  2. Acupuncture Points (Acupuncture Point) : 3 studies in 3 results
  3. Transplantation (Transplant Recipients) : 1 result
  4. Intramuscular Injections : 1 result
  5. Denervation : 1 result

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