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Central Sleep Apnea (Central Sleep Apnea Syndrome) Summary

Description: A condition associated with multiple episodes of sleep apnea which are distinguished from obstructive sleep apnea (SLEEP APNEA, OBSTRUCTIVE) by the complete cessation of efforts to breathe. This disorder is associated with dysfunction of central nervous system centers that regulate respiration. This condition may be idiopathic (primary) or associated with lower brain stem lesions; chronic obstructive pulmonary disease (LUNG DISEASES, OBSTRUCTIVE); HEART FAILURE, CONGESTIVE; medication effect; and other conditions. Sleep maintenance is impaired, resulting in daytime hypersomnolence. Primary central sleep apnea is frequently associated with obstructive sleep apnea. When both forms are present the condition is referred to as mixed sleep apnea (see SLEEP APNEA SYNDROMES). (Adams et al., Principles of Neurology, 6th ed, p395; Neurol Clin 1996;14(3):611-28)

Also Known As: Central Sleep Apnea Syndrome; Sleep Apnea, Central; Apnea, Central; Central Sleep Apnea, Primary; Central Sleep Apnea, Secondary Show All >>

Networked: 428 relevant articles (35 outcomes, 39 trials/studies) for this Disease

Key Drugs and Agents for Central Sleep Apnea

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Oxygen : 7 outcomes 8 studies in 86 results : IBA
  2. Acetazolamide (Diamox) : 3 outcomes 2 studies in 17 results : FDA 13 Generic
  3. Oxyhemoglobins (Oxyhemoglobin) : 3 outcomes in 13 results : IBA
  4. Carbon Dioxide : 2 outcomes 2 studies in 11 results : IBA
  5. Theophylline (Theon) : 2 outcomes 1 study in 13 results : FDA 119 Generic
  6. Congenital central hypoventilation syndrome : 2 outcomes in 10 results : IBA
  7. SAS : 1 outcome 2 studies in 13 results : IBA
  8. mirtazapine (Rexer) : 1 outcome 1 study in 2 results : FDA 21 Generic
  9. Benzodiazepines : 1 outcome in 6 results : IBA
  10. Brain Natriuretic Peptide (Natrecor) : 1 outcome in 3 results : FDA 1
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Diseases Related to Central Sleep Apnea

  1. Apnea
  2. Heart Failure
  3. Sleep Apnea Syndromes (Sleep Apnea)
  4. Central Sleep Apnea (Central Sleep Apnea Syndrome)
  5. Cheyne-Stokes Respiration
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Key Therapies for Central Sleep Apnea

Efficacy Chart >>
  1. Continuous Positive Airway Pressure : 6 outcomes 12 studies in 64 results
  2. Tracheostomy : 2 outcomes 1 study in 12 results
  3. Cardiac Resynchronization Therapy : 2 outcomes in 5 results
  4. Mechanical Ventilators (Ventilator) : 1 outcome 1 study in 21 results
  5. Positive-Pressure Respiration (PEEP) : 1 outcome in 5 results
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