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Caspases Summary

Description: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.

Key Diseases for which Caspases is Relevant

  1. Neoplasms (Cancer) : 7 outcomes 21 studies in 356 results
  2. Necrosis : 3 outcomes 5 studies in 148 results
  3. Inflammation : 3 outcomes 5 studies in 130 results
  4. Breast Neoplasms (Breast Cancer) : 2 outcomes 12 studies in 59 results
  5. Ischemia : 2 outcomes 6 studies in 49 results
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Drugs Related to Caspases

  1. Caspase 3 (Caspase-3)
  2. Proteins (Proteins, Gene)
  3. Reactive Oxygen Species (Oxygen Radicals)
  4. NF-kappa B (NF-kB)
  5. Cytochromes c (Cytochrome c)
  6. Peptide Hydrolases (Proteases)
  7. Phosphotransferases (Kinase)
  8. Death Domain Receptors
  9. Etoposide (VP 16)
  10. Caspase 9
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Therapies Related to Caspases

  1. Drug Therapy (Chemotherapy)
  2. Heterologous Transplantation (Xenotransplantation)
  3. Aftercare (After-Treatment)
  4. Resuscitation
  5. Chinese Traditional Medicine (Traditional Chinese Medicine)
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