Search Login Register

Ribosomal Protein S6 Kinases (S6 Kinase) Summary

Description: A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.

Also Known As: S6 Kinase; Ribosomal Protein S6 Kinase; S6-H4 Kinase; S6 H4 Kinase

Networked: 292 relevant articles (4 outcomes, 32 trials/studies) for this Bio-Agent

Key Diseases for which Ribosomal Protein S6 Kinases is Relevant

  1. Insulin Resistance : 1 outcome 3 studies in 20 results
  2. Fibrosis (Cirrhosis) : 1 outcome 1 study in 5 results
  3. Neoplasm Metastasis (Metastasis) : 1 outcome in 4 results
  4. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) : 1 outcome in 2 results
  5. Neurodegenerative Diseases (Neurodegenerative Disease) : 1 outcome in 1 result
Show All >>

Drugs Related to Ribosomal Protein S6 Kinases

  1. 70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
  2. Proto-Oncogene Proteins c-akt (Protein Kinase B)
  3. Proline (L-Proline)
  4. AMP-Activated Protein Kinases
  5. Small Interfering RNA (siRNA)
  6. Cytokines
  7. Interleukin-17 (Interleukin 27)
  8. Saquinavir (Invirase)
  9. Interferon-gamma (Interferon, gamma)
  10. ((3Z)- N- (3- chlorophenyl)- 3- ((3,5- dimethyl- 4- ((4- methylpiperazin- 1- yl)carbonyl)- 1H- pyrrol- 2- yl)methylene)- N- methyl- 2- oxo- 2,3- dihydro- 1H- indole- 5- sulfonamide)
Show All >>

Therapies Related to Ribosomal Protein S6 Kinases

  1. Nephrectomy
  2. Electroacupuncture
  3. Prostatectomy (Retropubic Prostatectomy)
  4. Hepatectomy
  5. Drug Therapy (Chemotherapy)
Show All >>

CureHunter Inc. provides medical information and specifically does NOT provide medical advice.
© Copyright 2003-2016 CureHunter Inc., MeSH copyright NLM, Journal Articles copyright original owners.