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Tissue Inhibitor of Metalloproteinases (TIMP) Summary

Description: A family of secreted proteins (TIMP-1; TIMP-2; and TIMP-3) that play a crucial role in regulating the activity of the secreted METALLOENDOPEPTIDASES; (COLLAGENASES; stromelysins; GELATINASES). Of the three characterized, only TIMP-1 and TIMP-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype in cancer cells. (Pharmacol Ther 1993;59:329-41)

Also Known As: TIMP; Collagenase Inhibitor; Inhibitor, Collagenase; Metalloproteinases Tissue Inhibitor

Networked: 1460 relevant articles (27 outcomes, 189 trials/studies) for this Bio-Agent

Key Diseases for which Tissue Inhibitor of Metalloproteinases is Relevant

  1. Neoplasms (Cancer) : 3 outcomes 24 studies in 252 results
  2. Fibrosis (Cirrhosis) : 3 outcomes 6 studies in 154 results
  3. Liver Cirrhosis (Hepatic Cirrhosis) : 3 outcomes 2 studies in 26 results
  4. Inflammation : 2 outcomes 4 studies in 76 results
  5. Heart Failure : 2 outcomes 4 studies in 21 results
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Drugs Related to Tissue Inhibitor of Metalloproteinases

  1. Metalloproteases (Metalloproteinases)
  2. Tissue Inhibitor of Metalloproteinase-2
  3. Collagen
  4. Matrix Metalloproteinases
  5. Tissue Inhibitor of Metalloproteinase-1
  6. Messenger RNA (mRNA)
  7. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  8. Transforming Growth Factors (Transforming Growth Factor)
  9. Proteins (Proteins, Gene)
  10. Biological Markers (Surrogate Marker)
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Therapies Related to Tissue Inhibitor of Metalloproteinases

  1. Lasers (Laser)
  2. Drug Therapy (Chemotherapy)
  3. Transplantation (Transplant Recipients)
  4. Stents
  5. Muscle Stretching Exercises (Stretching, Static)
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