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Calcineurin Summary

Description: A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

Also Known As: Protein Phosphatase 3; Protein Phosphatase 3 Catalytic Subunit; Protein Phosphatase 3 Regulatory Subunit; Phosphatase 3, Protein; Protein Phosphatase 2B Show All >>

Networked: 2469 relevant articles (133 outcomes, 240 trials/studies) for this Bio-Agent

Key Diseases for which Calcineurin is Relevant

  1. Atopic Dermatitis (Atopic Eczema) : 13 outcomes 11 studies in 131 results
  2. Proteinuria : 10 outcomes 3 studies in 55 results
  3. Infection : 8 outcomes 6 studies in 139 results
  4. Graft vs Host Disease (Graft-Versus-Host Disease) : 7 outcomes 4 studies in 50 results
  5. Nephrotic Syndrome (Syndrome, Nephrotic) : 6 outcomes 7 studies in 31 results
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Drugs Related to Calcineurin

  1. Sirolimus (Rapamycin)
  2. Tacrolimus (Prograf)
  3. Cyclosporine (Ciclosporin)
  4. pimecrolimus (Elidel)
  5. Steroids
  6. Calcium
  7. Adrenal Cortex Hormones (Corticosteroids)
  8. mycophenolate mofetil (Cellcept)
  9. Glucocorticoids
  10. everolimus
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Therapies Related to Calcineurin

  1. Transplantation (Transplant Recipients)
  2. Transplants (Transplant)
  3. Homologous Transplantation (Allograft)
  4. Kidney Transplantation
  5. Cell Transplantation
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