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Calcineurin
Summary
Description:
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Also Known As:
Protein Phosphatase 3; Protein Phosphatase 3 Catalytic Subunit; Protein Phosphatase 3 Regulatory Subunit; Phosphatase 3, Protein; Protein Phosphatase 2B Show All >>
Networked: 2469
relevant articles (133 outcomes,
240 trials/studies)
for this Bio-Agent
Key Diseases for which Calcineurin is
Relevant
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Atopic Dermatitis (Atopic Eczema)
:
13 outcomes 11 studies in 131 results
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Proteinuria
:
10 outcomes 3 studies in 55 results
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Infection
:
8 outcomes 6 studies in 139 results
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Graft vs Host Disease (Graft-Versus-Host Disease)
:
7 outcomes 4 studies in 50 results
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Nephrotic Syndrome (Syndrome, Nephrotic)
:
6 outcomes 7 studies in 31 results
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Drugs Related to Calcineurin
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Sirolimus (Rapamycin)
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Tacrolimus (Prograf)
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Cyclosporine (Ciclosporin)
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pimecrolimus (Elidel)
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Steroids
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Calcium
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Adrenal Cortex Hormones (Corticosteroids)
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mycophenolate mofetil (Cellcept)
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Glucocorticoids
-
everolimus
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Therapies Related to Calcineurin
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Transplantation (Transplant Recipients)
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Transplants (Transplant)
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Homologous Transplantation (Allograft)
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Kidney Transplantation
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Cell Transplantation
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