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Multiple System Atrophy Summary

Description: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)

Also Known As: Multiple System Atrophy Syndrome; Multisystem Atrophy; Multisystemic Atrophy; Atrophies, Multisystem; Atrophies, Multisystemic Show All >>

Networked: 1045 relevant articles (17 outcomes, 104 trials/studies) for this Disease

Key Drugs and Agents for Multiple System Atrophy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Levodopa (L Dopa) : 2 outcomes 6 studies in 67 results : FDA 31 Generic
  2. alpha-Synuclein : 1 outcome 16 studies in 194 results : IBA
  3. 3-Iodobenzylguanidine (Iobenguane) : 1 outcome 3 studies in 24 results : IBA
  4. Rifampin (Rifampicin) : 1 outcome 2 studies in 4 results : FDA 13 Generic
  5. Minocycline (Cyclops) : 1 outcome 2 studies in 2 results : FDA 25 Generic
  6. rasagiline (Azilect) : 1 outcome 2 studies in 2 results : FDA 1
  7. Type A Botulinum Toxins (Botulinum A Toxin) : 1 outcome 1 study in 1 result : FDA 2
  8. Camptocormia : 1 outcome in 9 results : IBA
  9. Dopamine beta-Hydroxylase : 1 outcome in 5 results : IBA
  10. Trimethaphan (Trimetaphan) : 1 outcome in 3 results : IBA
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Diseases Related to Multiple System Atrophy

  1. Parkinson Disease (Parkinson's Disease)
  2. Orthostatic Hypotension (Postural Hypotension)
  3. Overactive Urinary Bladder (Overactive Bladder)
  4. Atrophy
  5. Parkinsonian Disorders (Parkinsonism)
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Key Therapies for Multiple System Atrophy

Efficacy Chart >>
  1. Continuous Positive Airway Pressure : 1 outcome in 6 results
  2. Deep Brain Stimulation : 2 studies in 10 results
  3. Transplants (Transplant) : 2 studies in 5 results
  4. Cell Transplantation : 2 studies in 2 results
  5. Denervation : 1 study in 9 results
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