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NADPH Oxidase (NAD(P)H oxidase) Summary

Description: A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.

Also Known As: NAD(P)H oxidase; Oxidase, NADPH

Networked: 2686 relevant articles (71 outcomes, 311 trials/studies) for this Bio-Agent

Key Diseases for which NADPH Oxidase is Relevant

  1. Inflammation : 3 outcomes 18 studies in 271 results
  2. Fibrosis (Cirrhosis) : 3 outcomes 6 studies in 95 results
  3. Insulin Resistance : 3 outcomes 4 studies in 37 results
  4. Cardiomegaly (Heart Hypertrophy) : 3 outcomes 3 studies in 39 results
  5. Hypertension (High Blood Pressure) : 2 outcomes 32 studies in 242 results
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Drugs Related to NADPH Oxidase

  1. acetovanillone (apocynin)
  2. Superoxides (Superoxide)
  3. Reactive Oxygen Species (Oxygen Radicals)
  4. 3-nitrotyrosine
  5. 4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)
  6. Nitric Oxide Synthase (NO Synthase)
  7. Antioxidants
  8. Insulin (Novolin)
  9. nebivolol
  10. Nitric Oxide (Nitrogen Monoxide)
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Therapies Related to NADPH Oxidase

  1. Ligation
  2. Resuscitation
  3. Endarterectomy (Thromboendarterectomy)
  4. Electrodes (Electrode)
  5. Aftercare (After-Treatment)
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