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Primary Progressive Aphasia Summary

Description: A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)

Also Known As: Aphasia, Primary Progressive; Mesulam's Syndrome; Aphasias, Primary Progressive; Primary Progressive Aphasias; Progressive Aphasia, Primary Show All >>

Networked: 75 relevant articles (2 outcomes, 11 trials/studies) for this Disease

Key Drugs and Agents for Primary Progressive Aphasia

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. TNFR-Fc fusion protein (etanercept) : 2 outcomes 1 study in 3 results : FDA 2
  2. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor) : 1 outcome 1 study in 1 result : IBA
  3. Amyloid (Amyloid Fibrils) : 3 studies in 9 results : IBA
  4. Apolipoproteins : 2 studies in 5 results : IBA
  5. Apolipoproteins E (ApoE) : 1 study in 6 results : IBA
  6. Fluorodeoxyglucose F18 (Fludeoxyglucose F 18) : 1 study in 3 results : FDA 2
  7. Memantine (Namenda) : 1 study in 1 result : FDA 12
  8. N- methyl- 2- (4'- methylaminophenyl)- 6- hydroxybenzothiazole : 1 study in 1 result : IBA
  9. Biological Markers (Surrogate Marker) : 11 results : IBA
  10. protein TDP-43 (TDP-43) : 5 results : IBA
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Diseases Related to Primary Progressive Aphasia

  1. Alzheimer Disease (Alzheimer's Disease)
  2. Dementia (Dementias)
  3. Frontotemporal Dementia
  4. Frontotemporal Lobar Degeneration (Semantic Dementia)
  5. Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
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Key Therapies for Primary Progressive Aphasia

Efficacy Chart >>
  1. Vasectomy (Vas Occlusion) : 1 study in 2 results
  2. Language Therapy (Language Training) : 1 study in 2 results
  3. Activities of Daily Living (ADL) : 6 results
  4. Speech Therapy (Therapy, Speech) : 1 result

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