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Multiple Endocrine Neoplasia Type 1 (MEN I) Summary

Description: A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).

Also Known As: MEN I; MEN 1; MEN1; MEA I; MEA 1 Show All >>

Networked: 1034 relevant articles (26 outcomes, 79 trials/studies) for this Disease

Key Drugs and Agents for Multiple Endocrine Neoplasia Type 1

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Gastrins : 3 outcomes 5 studies in 60 results : IBA
  2. cinacalcet (Sensipar) : 3 outcomes in 4 results : FDA 3
  3. Octreotide (Sandostatin) : 2 outcomes in 10 results : FDA 14 Generic
  4. DNA (Deoxyribonucleic Acid) : 1 outcome 4 studies in 116 results : IBA
  5. Calcium : 1 outcome 2 studies in 31 results : IBA
  6. Glucose (Dextrose) : 1 outcome 2 studies in 12 results : FDA 175 Generic
  7. Ethanol (Ethyl Alcohol) : 1 outcome 2 studies in 6 results : IBA
  8. Complementary DNA (cDNA) : 1 outcome 1 study in 13 results : IBA
  9. Genetic Markers (Genetic Marker) : 1 outcome 1 study in 12 results : IBA
  10. Secretin : 1 outcome 1 study in 7 results : FDA 2
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Diseases Related to Multiple Endocrine Neoplasia Type 1

  1. Multiple Endocrine Neoplasia Type 1 (MEN I)
  2. Primary Hyperparathyroidism
  3. Neoplasms (Cancer)
  4. Gastrinoma
  5. Primitive Neuroectodermal Tumors (PNET)
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Key Therapies for Multiple Endocrine Neoplasia Type 1

Efficacy Chart >>
  1. Parathyroidectomy : 5 outcomes 8 studies in 64 results
  2. Thymectomy : 2 outcomes 1 study in 15 results
  3. Gastrectomy : 1 outcome 1 study in 9 results
  4. Pancreatectomy : 1 outcome in 12 results
  5. Pancreaticoduodenectomy : 1 outcome in 6 results
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