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Neurofibrosarcoma (Neurofibrosarcomas) Summary

Description: A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65(2):164-72)

Also Known As: Neurofibrosarcomas; Neurogenic Sarcomas; Neurogenic Sarcoma; Sarcomas, Neurogenic; Sarcoma, Neurogenic

Networked: 94 relevant articles (1 outcomes, 10 trials/studies) for this Disease

Key Drugs and Agents for Neurofibrosarcoma

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. follicular Thyroid cancer : 1 outcome in 1 result : IBA
  2. malignant Schwannoma : 2 studies in 16 results : IBA
  3. Neurofibromin 1 (Neurofibromin) : 1 study in 5 results : IBA
  4. Dermatofibrosarcoma protuberans : 1 study in 5 results : IBA
  5. S100 Proteins (S 100 Protein) : 1 study in 4 results : IBA
  6. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor) : 1 study in 2 results : IBA
  7. Estrogen Receptor alpha : 1 study in 1 result : IBA
  8. Angiogenesis Modulating Agents : 1 study in 1 result : IBA
  9. Vascular Endothelial Growth Factor Receptors (VEGF Receptors) : 1 study in 1 result : IBA
  10. Thymidine : 1 study in 1 result : IBA
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Diseases Related to Neurofibrosarcoma

  1. Neoplasms (Cancer)
  2. Sarcoma (Soft Tissue Sarcoma)
  3. Melanoma (Melanoma, Malignant)
  4. Liposarcoma
  5. Fibrosarcoma
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Key Therapies for Neurofibrosarcoma

Efficacy Chart >>
  1. Radiotherapy : 4 results
  2. Drug Therapy (Chemotherapy) : 3 results
  3. Heterologous Transplantation (Xenotransplantation) : 2 results
  4. Free Tissue Flaps : 1 result
  5. Sternotomy : 1 result
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